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Difference between revisions of "Neuropathology tumours"
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→Primary vs. secondary: +table of common tumours
(+mets) |
(→Primary vs. secondary: +table of common tumours) |
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| Line 60: | Line 60: | ||
**Processes may branch. | **Processes may branch. | ||
*Ill-defined border/blend with the surrounding brain/. | *Ill-defined border/blend with the surrounding brain/. | ||
===Common brain tumours in a table=== | |||
{| class="wikitable" | |||
|'''Type''' | |||
|'''Key feature(s)''' | |||
|'''Imaging''' | |||
|'''History''' | |||
|'''Notes''' | |||
|'''IHC''' | |||
|'''Images''' | |||
|- | |||
|Normal | |||
|regular spacing, no atypia | |||
|nil | |||
|variable | |||
|missed lesion? | |||
|nil | |||
|[http://commons.wikimedia.org/wiki/File:Grey_matter_and_white_matter_-_very_high_mag.jpg], [http://commons.wikimedia.org/wiki/File:Grey_matter_and_white_matter_-_high_mag.jpg] | |||
|- | |||
|Astrocytoma | |||
|glial processes (on smear), nuclear atypia | |||
|enhancing, usu. supratentorial, usu. white matter lesion | |||
|usu. old, occ. young | |||
|very common | |||
|IDH-1+/- | |||
|[http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_high_mag.jpg], [http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_very_high_mag_-_cropped.jpg] | |||
|- | |||
|Metastasis | |||
|sharp interface with brain, often glandular, nucleoli | |||
|often cerebellular, well-circumscribed | |||
|usu. old | |||
|often suspected | |||
|TTF-1, CK7, CK20 | |||
|[http://commons.wikimedia.org/w/index.php?title=File:Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg], [http://commons.wikimedia.org/w/index.php?title=File:Metastatic_adenocarcinoma_-_cerebellum_-_high_mag.jpg] | |||
|- | |||
|Meningioma | |||
|whorls, psammomatous calcs, nuclear inclusions | |||
|extra-axial + intradural | |||
|old or young | |||
|can be diagnosed on smear, DDx: choroid plexus | |||
|EMA, PR, Ki-67 | |||
|[http://commons.wikimedia.org/wiki/File:Meningioma_intermed_mag.jpg] | |||
|- | |||
|Schwannoma | |||
|cellular areas (Antoni A), paucicelluar areas (Antoni B) | |||
|extra-axial + intradural | |||
|old or young | |||
|need frozen section to Dx | |||
|S100 | |||
|[http://commons.wikimedia.org/wiki/File:Peripheral_schwannoma_Antoni_type_A_(1).JPG] | |||
|} | |||
==Metastatic tumours== | ==Metastatic tumours== | ||