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'''Primary sclerosing cholangitis''', abbreviated '''PSC''', is an uncommon [[medical liver disease]] that can afflicts the young | '''Primary sclerosing cholangitis''', abbreviated '''PSC''', is an uncommon [[medical liver disease]] that can afflicts the young and old, and is often associated with [[ulcerative colitis]]. | ||
'''Pericholangitis''' is considered a synonym for ''small duct PSC''.<ref>URL: [http://emedicine.medscape.com/article/181889-overview http://emedicine.medscape.com/article/181889-overview]. Accessed on: 25 January 2012.</ref> | '''Pericholangitis''' is considered a synonym for ''small duct PSC''.<ref>URL: [http://emedicine.medscape.com/article/181889-overview http://emedicine.medscape.com/article/181889-overview]. Accessed on: 25 January 2012.</ref> | ||
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* | *IgG4-associated cholangitis - see [[IgG4-related disease]].<ref name=pmid19633647>{{Cite journal | last1 = Deshpande | first1 = V. | last2 = Sainani | first2 = NI. | last3 = Chung | first3 = RT. | last4 = Pratt | first4 = DS. | last5 = Mentha | first5 = G. | last6 = Rubbia-Brandt | first6 = L. | last7 = Lauwers | first7 = GY. | title = IgG4-associated cholangitis: a comparative histological and immunophenotypic study with primary sclerosing cholangitis on liver biopsy material. | journal = Mod Pathol | volume = 22 | issue = 10 | pages = 1287-95 | month = Oct | year = 2009 | doi = 10.1038/modpathol.2009.94 | PMID = 19633647 }}</ref> | ||
*Others. | |||
===Staging=== | ===Staging=== | ||
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Notes: | Notes: | ||
*Similar to PBC staging. | *Similar to [[PBC]] staging. | ||
===Images=== | ===Images=== | ||
*[http://trialx.com/curetalk/wp-content/blogs.dir/7/files/2011/05/diseases/Primary_Sclerosing_Cholangitis-2.jpg PSC (trialx.com)].<ref>URL: [http://trialx.com/curebyte/2011/07/08/clinical-trials-and-images-of-primary-sclerosing-cholangitis/ http://trialx.com/curebyte/2011/07/08/clinical-trials-and-images-of-primary-sclerosing-cholangitis/]. Accessed on: 1 January 2012.</ref> | *[http://trialx.com/curetalk/wp-content/blogs.dir/7/files/2011/05/diseases/Primary_Sclerosing_Cholangitis-2.jpg PSC (trialx.com)].<ref>URL: [http://trialx.com/curebyte/2011/07/08/clinical-trials-and-images-of-primary-sclerosing-cholangitis/ http://trialx.com/curebyte/2011/07/08/clinical-trials-and-images-of-primary-sclerosing-cholangitis/]. Accessed on: 1 January 2012.</ref> | ||
*[http://www.onmedica.com/getresource.aspx?resourceid=e398a3f2-e030-40e6-823b-2e8e2cbbe4bb PSC (onmedica.com)].<ref>URL: [http://www.onmedica.com/NewsArticle.aspx?id=d7f992b5-6dee-46c6-8383-bbdfb4528ccc http://www.onmedica.com/NewsArticle.aspx?id=d7f992b5-6dee-46c6-8383-bbdfb4528ccc]. Accessed on: 1 January 2011.</ref> | *[http://www.onmedica.com/getresource.aspx?resourceid=e398a3f2-e030-40e6-823b-2e8e2cbbe4bb PSC (onmedica.com)].<ref>URL: [http://www.onmedica.com/NewsArticle.aspx?id=d7f992b5-6dee-46c6-8383-bbdfb4528ccc http://www.onmedica.com/NewsArticle.aspx?id=d7f992b5-6dee-46c6-8383-bbdfb4528ccc]. Accessed on: 1 January 2011.</ref> | ||
*[http://www.nature.com/nrgastro/journal/v7/n11/fig_tab/nrgastro.2010.155_F2.html PSC (nature.com)].<ref>{{Cite journal | last1 = Mendes | first1 = F. | last2 = Lindor | first2 = KD. | title = Primary sclerosing cholangitis: overview and update. | journal = Nat Rev Gastroenterol Hepatol | volume = 7 | issue = 11 | pages = 611-9 | month = Nov | year = 2010 | doi = 10.1038/nrgastro.2010.155 | PMID = 20938459 }}</ref> | |||
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[[File:1 PSC 1 680x512px.tif| Primary sclerosing cholangitis in patient with history of ulcerative colitis.]] | |||
[[File:2 PSC 1 680x512px.tif| Primary sclerosing cholangitis in patient with history of ulcerative colitis.]] | |||
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[[File:3 PSC 1 680x512px.tif| Primary sclerosing cholangitis in patient with history of ulcerative colitis.]] | |||
[[File:4 PSC 1 680x512px.tif| Primary sclerosing cholangitis in patient with history of ulcerative colitis.]] | |||
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[[File:5 PSC 1 680x512px.tif| Primary sclerosing cholangitis in patient with history of ulcerative colitis.]] | |||
[[File:6 PSC 1 680x512px.tif| Primary sclerosing cholangitis in patient with history of ulcerative colitis.]] | |||
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<br>Primary sclerosing cholangitis in patient with history of ulcerative colitis. <br>Low power shows inflamed bands [green arrows] and a rare scar at the edge of a triad [black arrow] (Row 1 Left 40X). A triad with a characteristic periductal fibrosis [black arrows] is seen (Row 1 Right 200X). Reticulin shows the space about the duct [green arrows], as well as some foci of piecemeal necrosis [blue arrows] (Row 2 Left 200X). Trichrome shows fibrous bridges [black arrows] (Row 2 Right 200X). Damage to bile ducts is seen by peripheral proliferated bile ductules [green arrows] with neutrophils [blue arrows] (Row 3 Left 400X). Also seen is a small periportal bile infarct with necrotic hepatocyte nuclei [black arrows] (Row 3 Right 400X). | |||
==See also== | ==See also== |