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Difference between revisions of "Pyloric gland adenoma"
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Pyloric gland adenoma (view source)
Revision as of 05:21, 6 September 2014
, 05:21, 6 September 2014no edit summary
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{{ Infobox diagnosis | |||
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| Micro = round mildly irregular foveolar-type glands with round, basal, bland nuclei | |||
| Subtypes = | |||
| LMDDx = foveolar-type [[gastric adenoma]], well-differentiated [[gastric adenocarcinoma]] | |||
| Stains = | |||
| IHC = MUC6 +ve, MUC5AC +ve, Ki-67 high | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[stomach]], [[duodenum]], [[gallbladder]], others | |||
| Assdx = well-differentiated [[gastric adenocarcinoma]], [[autoimmune gastritis]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = polyp | |||
| Prognosis = benign | |||
| Other = | |||
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| Tx = | |||
}} | |||
'''Pyloric gland adenoma''', abbreviated '''PGA''', is an uncommon [[gastrointestinal pathology|gastrointestinal]] lesion. | '''Pyloric gland adenoma''', abbreviated '''PGA''', is an uncommon [[gastrointestinal pathology|gastrointestinal]] lesion. | ||
==General== | ==General== | ||
* | *Approximately 3% of gastric polyps.<ref name=pmid16506593>{{Cite journal | last1 = Vieth | first1 = M. | last2 = Vogel | first2 = C. | last3 = Kushima | first3 = R. | last4 = Borchard | first4 = F. | last5 = Stolte | first5 = M. | title = Pyloric gland adenoma-- how to diagnose? | journal = Cesk Patol | volume = 42 | issue = 1 | pages = 4-7 | month = Jan | year = 2006 | doi = | PMID = 16506593 }}</ref> | ||
*Associated with [[autoimmune gastritis]].<ref>{{Cite journal | last1 = Vieth | first1 = M. | last2 = Montgomery | first2 = EA. | title = Some observations on pyloric gland adenoma: an uncommon and long ignored entity! | journal = J Clin Pathol | volume = | issue = | pages = | month = Aug | year = 2014 | doi = 10.1136/jclinpath-2014-202553 | PMID = 25092673 }}</ref> | *Associated with [[autoimmune gastritis]].<ref>{{Cite journal | last1 = Vieth | first1 = M. | last2 = Montgomery | first2 = EA. | title = Some observations on pyloric gland adenoma: an uncommon and long ignored entity! | journal = J Clin Pathol | volume = | issue = | pages = | month = Aug | year = 2014 | doi = 10.1136/jclinpath-2014-202553 | PMID = 25092673 }}</ref> | ||
*More often seen in women as with autoimmune gastritis. | |||
*Associated with [[gastric adenocarcinoma]]. | |||
==Microscopic== | ==Microscopic== | ||
Features: | |||
*Round mildly irregular foveolar-type glands with: | |||
**Nuclei without dysplasia (round and basally located nuclei) or with dysplasia. | |||
**Moderate eosinophilic (or clear) cytoplasm. | |||
DDx: | DDx: | ||