Difference between revisions of "Pyloric gland adenoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Synonyms  =
| Micro      = round mildly irregular foveolar-type glands with round, basal, bland nuclei
| Subtypes  =
| LMDDx      = foveolar-type [[gastric adenoma]], well-differentiated [[gastric adenocarcinoma]]
| Stains    =
| IHC        = MUC6 +ve, MUC5AC +ve, Ki-67 high
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[stomach]], [[duodenum]], [[gallbladder]], others
| Assdx      = well-differentiated [[gastric adenocarcinoma]], [[autoimmune gastritis]]
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  = polyp
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Pyloric gland adenoma''', abbreviated '''PGA''', is an uncommon [[gastrointestinal pathology|gastrointestinal]] lesion.
'''Pyloric gland adenoma''', abbreviated '''PGA''', is an uncommon [[gastrointestinal pathology|gastrointestinal]] lesion.


==General==
==General==
*Less than 3% of gastric polyps.<ref name=pmid16506593>{{Cite journal  | last1 = Vieth | first1 = M. | last2 = Vogel | first2 = C. | last3 = Kushima | first3 = R. | last4 = Borchard | first4 = F. | last5 = Stolte | first5 = M. | title = Pyloric gland adenoma-- how to diagnose? | journal = Cesk Patol | volume = 42 | issue = 1 | pages = 4-7 | month = Jan | year = 2006 | doi =  | PMID = 16506593 }}</ref>
*Approximately 3% of gastric polyps.<ref name=pmid16506593>{{Cite journal  | last1 = Vieth | first1 = M. | last2 = Vogel | first2 = C. | last3 = Kushima | first3 = R. | last4 = Borchard | first4 = F. | last5 = Stolte | first5 = M. | title = Pyloric gland adenoma-- how to diagnose? | journal = Cesk Patol | volume = 42 | issue = 1 | pages = 4-7 | month = Jan | year = 2006 | doi =  | PMID = 16506593 }}</ref>
*Associated with [[autoimmune gastritis]].<ref>{{Cite journal  | last1 = Vieth | first1 = M. | last2 = Montgomery | first2 = EA. | title = Some observations on pyloric gland adenoma: an uncommon and long ignored entity! | journal = J Clin Pathol | volume =  | issue =  | pages =  | month = Aug | year = 2014 | doi = 10.1136/jclinpath-2014-202553 | PMID = 25092673 }}</ref>
*Associated with [[autoimmune gastritis]].<ref>{{Cite journal  | last1 = Vieth | first1 = M. | last2 = Montgomery | first2 = EA. | title = Some observations on pyloric gland adenoma: an uncommon and long ignored entity! | journal = J Clin Pathol | volume =  | issue =  | pages =  | month = Aug | year = 2014 | doi = 10.1136/jclinpath-2014-202553 | PMID = 25092673 }}</ref>
*More often seen in women as with autoimmune gastritis.
*Associated with [[gastric adenocarcinoma]].


==Microscopic==
==Microscopic==
Features:
*Round mildly irregular foveolar-type glands with:
**Nuclei without dysplasia (round and basally located nuclei) or with dysplasia.
**Moderate eosinophilic (or clear) cytoplasm. 


DDx:
DDx:
48,830

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