Difference between revisions of "Small intestine"

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Small intestine (view source)

Revision as of 19:06, 4 September 2014

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→‎Autoimmune enteropathy: split out
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==Autoimmune enteropathy==
==Autoimmune enteropathy==
*Abbreviated as ''AIE''.
*Abbreviated as ''AIE''.
===General===
{{Main|Autoimmune enteropathy}}
*Considered a pediatric disease.
*Super rare in adults - there are only ~11 reported cases in the literature.<ref name=pmid17683994>{{Cite journal  | last1 = Akram | first1 = S. | last2 = Murray | first2 = JA. | last3 = Pardi | first3 = DS. | last4 = Alexander | first4 = GL. | last5 = Schaffner | first5 = JA. | last6 = Russo | first6 = PA. | last7 = Abraham | first7 = SC. | title = Adult autoimmune enteropathy: Mayo Clinic Rochester experience. | journal = Clin Gastroenterol Hepatol | volume = 5 | issue = 11 | pages = 1282-90; quiz 1245 | month = Nov | year = 2007 | doi = 10.1016/j.cgh.2007.05.013 | PMID = 17683994 | PMC = 2128725 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128725/ }}</ref>
*May be a component of the IPEX syndrome.<ref>{{Cite journal  | last1 = Gentile | first1 = NM. | last2 = Murray | first2 = JA. | last3 = Pardi | first3 = DS. | title = Autoimmune enteropathy: a review and update of clinical management. | journal = Curr Gastroenterol Rep | volume = 14 | issue = 5 | pages = 380-5 | month = Oct | year = 2012 | doi = 10.1007/s11894-012-0276-2 | PMID = 22810979 }}</ref>
 
Diagnosis is clinico-pathologic:<ref name=pmid17683994/>
#Intact immune system.
#Autoantibodies.
#*Anti-enterocyte antibody.
#*Anti-goblet antibody.
#Lack of response to gluten-free diet.
 
===Microscopic===
Features:<ref name=pmid17683994/>
*+/-Loss of goblet cells.
*+/-Loss of paneth cells.
*Villous blunting.
 
DDx:
*[[Celiac disease]].


=See also=
=See also=
Michael
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