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Difference between revisions of "Adrenocortical carcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Adrenal_cortical_carcinoma_-_low_mag.jpg | |||
| Width = | |||
| Caption = Adrenocortical carcinoma. [[H&E stain]]. | |||
| Synonyms = adrenal cortical carcinoma | |||
| Micro = see below - various criteria, dependent on adult vs pediatric | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = | |||
| IHC = vimentin +ve, melan A +ve, inhibin-alpha +ve, chromogranin A -ve, [[EMA]] -ve, S-100 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[adrenal gland]] - cortex | |||
| Assdx = | |||
| Syndromes = [[Li-Fraumeni syndrome]], [[Beckwith-Wiedemann syndrome]] | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = adrenal mass, typically large | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = [[renal cell carcinoma]], other abdominal masses | |||
| Tx = surgical excision if feasible | |||
}} | |||
'''Adrenocortical carcinoma''', abbreviated '''ACC''', is a malignant tumour of the [[adrenal gland]] cortex. | '''Adrenocortical carcinoma''', abbreviated '''ACC''', is a malignant tumour of the [[adrenal gland]] cortex. | ||
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<gallery> | <gallery> | ||
Image:Adrenal_cortical_carcinoma_-_low_mag.jpg | ACC - low mag. (WC/Nephron) | Image:Adrenal_cortical_carcinoma_-_low_mag.jpg | ACC - low mag. (WC/Nephron) | ||
Image:Adrenal_cortical_carcinoma_-_intermed_mag.jpg | ACC - intermed. mag. (WC/Nephron) | |||
Image:Adrenal_cortical_carcinoma_-_m_-_high_mag.jpg | ACC - high mag. (WC/Nephron) | Image:Adrenal_cortical_carcinoma_-_m_-_high_mag.jpg | ACC - high mag. (WC/Nephron) | ||
Image:Adrenal_cortical_carcinoma_-_high_mag.jpg | ACC with normal adrenal medulla - high mag. (WC/Nephron) | Image:Adrenal_cortical_carcinoma_-_high_mag.jpg | ACC with normal adrenal medulla - high mag. (WC/Nephron) | ||
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#Necrosis in nests. | #Necrosis in nests. | ||
#Venous invasion. | #Venous invasion. | ||
#Adrenal sinusoid invasion; lymphovascular space invasion within the adrenal gland. | #Adrenal sinusoid invasion; [[lymphovascular space invasion]] within the [[adrenal gland]]. | ||
#Capsular invasion. | #Capsular invasion. | ||