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Difference between revisions of "Seminoma"
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→IHC
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==IHC== | ==IHC== | ||
===ISUP consensus=== | |||
A general panel:<ref name=pmid24832161>{{cite journal |author=Ulbright TM, Tickoo SK, Berney DM, Srigley JR |title=Best practices recommendations in the application of immunohistochemistry in testicular tumors: report from the international society of urological pathology consensus conference |journal=Am. J. Surg. Pathol. |volume=38 |issue=8 |pages=e50–9 |year=2014 |month=August |pmid=24832161 |doi=10.1097/PAS.0000000000000233 |url=}}</ref> | |||
*OCT4 +ve. | *OCT4 +ve. | ||
**Choriocarcinoma, yolk sac tumour and spermatocytic seminoma all -ve. | **Choriocarcinoma, yolk sac tumour and spermatocytic seminoma all -ve. | ||
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**+ve in embryonal carcinoma. | **+ve in embryonal carcinoma. | ||
Seminoma versus choriocarcinoma:<ref name=pmid25025364>{{Cite journal | last1 = Amin | first1 = MB. | last2 = Epstein | first2 = JI. | last3 = Ulbright | first3 = TM. | last4 = Humphrey | first4 = PA. | last5 = Egevad | first5 = L. | last6 = Montironi | first6 = R. | last7 = Grignon | first7 = D. | last8 = Trpkov | first8 = K. | last9 = Lopez-Beltran | first9 = A. | title = Best practices recommendations in the application of immunohistochemistry in urologic pathology: report from the international society of urological pathology consensus conference. | journal = Am J Surg Pathol | volume = 38 | issue = 8 | pages = 1017-22 | month = Aug | year = 2014 | doi = 10.1097/PAS.0000000000000254 | PMID = 25025364 }}</ref> | |||
*OCT4 (uniformily) +ve. | *OCT4 (uniformily) +ve. | ||
**Choriocarcinoma = patchy staining. | **Choriocarcinoma = patchy staining. | ||
Additional notes | ===Additional notes=== | ||
*D2-40 +ve ~100% of cases in one series.<ref name=pmid17277761>{{Cite journal | last1 = Lau | first1 = SK. | last2 = Weiss | first2 = LM. | last3 = Chu | first3 = PG. | title = D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. | journal = Mod Pathol | volume = 20 | issue = 3 | pages = 320-5 | month = Mar | year = 2007 | doi = 10.1038/modpathol.3800749 | PMID = 17277761 }}</ref> | *D2-40 +ve ~100% of cases in one series.<ref name=pmid17277761>{{Cite journal | last1 = Lau | first1 = SK. | last2 = Weiss | first2 = LM. | last3 = Chu | first3 = PG. | title = D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. | journal = Mod Pathol | volume = 20 | issue = 3 | pages = 320-5 | month = Mar | year = 2007 | doi = 10.1038/modpathol.3800749 | PMID = 17277761 }}</ref> | ||
**Useful for discriminating from [[embryonal carcinoma]].<ref name=pmid18045648/> | **Useful for discriminating from [[embryonal carcinoma]].<ref name=pmid18045648/> | ||