Difference between revisions of "Bone"

Bone (view source)

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 {{Main|Forensic pathology}}
 This is dealt with in the ''forensic pathology'' article.
+==Others==
+The following is a collection of weird stuffs.
+==Paget disease of the bone==
+===General===
+*Benign - unlike [[Paget disease of the breast]].
+Classically divided into three phases:<ref name=emed_paget>URL: [http://emedicine.medscape.com/article/311688-overview http://emedicine.medscape.com/article/311688-overview]. Accessed on: 25 December 2010.</ref><ref>URL: [http://radiopaedia.org/articles/paget-disease-of-bone-1 http://radiopaedia.org/articles/paget-disease-of-bone-1]. Accessed on: 25 December 2010.</ref>
+#Lytic (predominantly osteoclasts).
+#Mixed lytic (osteoclastic) and blastic (osteoblastic).
+#Sclerotic (burned-out).
+Clinical:
+*Elevated ALP.
+===Microscopic===
+Features:<ref name=emed_paget>URL: [http://emedicine.medscape.com/article/311688-overview http://emedicine.medscape.com/article/311688-overview]. Accessed on: 25 December 2010.</ref>
+*Bone matrix has jigsaw-puzzle like pattern.
+**Jigsaw-puzzle pieces ~ 100-500 micrometres.
+*Increased osteoclast activity.
+**Osteoclast = macrophage that resorbs bone matrix.
+Images:
+*[http://commons.wikimedia.org/wiki/File:Paget_disease_of_bone_-_high_mag.jpg Paget disease - bone - high mag. (WC)].
+*[http://commons.wikimedia.org/wiki/File:Paget_disease_of_bone_-_intermed_mag.jpg Paget disease - bone - intermed. mag. (WC)].
 ==See also==