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Difference between revisions of "Seminoma"
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==IHC== | ==IHC== | ||
*D2-40 +ve ~100% of cases.<ref name=pmid17277761>{{Cite journal | last1 = Lau | first1 = SK. | last2 = Weiss | first2 = LM. | last3 = Chu | first3 = PG. | title = D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. | journal = Mod Pathol | volume = 20 | issue = 3 | pages = 320-5 | month = Mar | year = 2007 | doi = 10.1038/modpathol.3800749 | PMID = 17277761 }}</ref> | [[ISUP]] consensus paper by Ulbright ''et al.'':<ref name=pmid24832161>{{cite journal |author=Ulbright TM, Tickoo SK, Berney DM, Srigley JR |title=Best practices recommendations in the application of immunohistochemistry in testicular tumors: report from the international society of urological pathology consensus conference |journal=Am. J. Surg. Pathol. |volume=38 |issue=8 |pages=e50–9 |year=2014 |month=August |pmid=24832161 |doi=10.1097/PAS.0000000000000233 |url=}}</ref> | ||
*OCT4 +ve. | |||
**Choriocarcinoma, yolk sac tumour and spermatocytic seminoma all -ve. | |||
*CD117 +ve. | |||
**-ve in embryonal carcinoma. | |||
*CD30 -ve. | |||
**+ve in embryonal carcinoma. | |||
Additional notes: | |||
*D2-40 +ve ~100% of cases in one series.<ref name=pmid17277761>{{Cite journal | last1 = Lau | first1 = SK. | last2 = Weiss | first2 = LM. | last3 = Chu | first3 = PG. | title = D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. | journal = Mod Pathol | volume = 20 | issue = 3 | pages = 320-5 | month = Mar | year = 2007 | doi = 10.1038/modpathol.3800749 | PMID = 17277761 }}</ref> | |||
**Useful for discriminating from [[embryonal carcinoma]].<ref name=pmid18045648/> | **Useful for discriminating from [[embryonal carcinoma]].<ref name=pmid18045648/> | ||
*CD117 +ve (ckit) ~92% of cases.<ref name=pmid17277761/> | *CD117 +ve (ckit) ~92% of cases.<ref name=pmid17277761/> | ||