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Difference between revisions of "Sinonasal undifferentiated carcinoma"
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Sinonasal undifferentiated carcinoma (view source)
Revision as of 07:00, 27 July 2014
, 07:00, 27 July 2014no edit summary
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Sinonasal_undifferentiated_carcinoma_-_high_mag.jpg | |||
| Width = | |||
| Caption = SNUC. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = tumour with variable architecture (nested, trabecular or lobular), small-to-moderate cytoplasm, +/-distinct nucleoli, cell size variable (small to large); glandular and squamous differentiation are absent by definition | |||
| Subtypes = | |||
| LMDDx = poorly differentiated [[squamous cell carcinoma of the head and neck]], [[small cell carcinoma]], others | |||
| Stains = | |||
| IHC = pankeratin +ve, [[EMA]] +ve, CK7 +ve, CK5/6 -ve, NSE +ve/-ve, chromogranin A -ve, synaptophysin -ve, p63 +ve/-ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[head and neck pathology|head and neck]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = other head and neck tumours | |||
| Tx = | |||
}} | |||
'''Sinonasal undifferentiated carcinoma''', abbreviated '''SNUC''', is a rare epithelial malignancy of the [[head and neck pathology|head and neck]]. | '''Sinonasal undifferentiated carcinoma''', abbreviated '''SNUC''', is a rare epithelial malignancy of the [[head and neck pathology|head and neck]]. | ||
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*Glandular and squamous differentiation are absent by definition.<ref name=pmid11904342/> | *Glandular and squamous differentiation are absent by definition.<ref name=pmid11904342/> | ||
DDx: | |||
*www: | *Poorly differentiated [[squamous cell carcinoma of the head and neck]]. | ||
*[[Small cell carcinoma]]. | |||
*Other tumours. | |||
===Images=== | |||
www: | |||
*[http://www.nature.com/modpathol/journal/v15/n3/fig_tab/3880522f7.html SNUC (nature.com)].<ref name=pmid11904342>{{Cite journal | last1 = Mills | first1 = SE. | title = Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. | journal = Mod Pathol | volume = 15 | issue = 3 | pages = 264-78 | month = Mar | year = 2002 | doi = 10.1038/modpathol.3880522 | PMID = 11904342 | URL = http://dx.doi.org/10.1038/modpathol.3880522 }}</ref> | |||
*[http://www.pathologypics.com/PictView.aspx?ID=244 SNUC (pathologypics.com)]. | |||
*[http://www.pathologypics.com/PictView.aspx?ID=249 SNUC (pathologypics.com)]. | |||
<gallery> | |||
Image:Sinonasal_undifferentiated_carcinoma_-_low_mag.jpg | SNUC - low mag. (WC) | |||
Image:Sinonasal_undifferentiated_carcinoma_-_high_mag.jpg | SNUC - high mag. (WC) | |||
Image:Sinonasal_undifferentiated_carcinoma_-_very_high_mag.jpg | SNUC - very high mag. (WC) | |||
</gallery> | |||
==IHC== | ==IHC== | ||