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Difference between revisions of "Germ cell tumours"
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→IHC for GCTs: more
(→IHC for GCTs: more) |
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===IHC for GCTs=== | ===IHC for GCTs=== | ||
ABCDs of GCTs | ====ABCDs of GCTs==== | ||
*AFP - yolk sac tumour. | *AFP - yolk sac tumour. | ||
*Beta-hCG - choriocarcinoma. | *Beta-hCG - choriocarcinoma. | ||
*CD30 - embryonal carcinoma. | *CD30 - embryonal carcinoma. | ||
*D2-40 - seminoma. | *D2-40 - seminoma. | ||
====GCT versus sex cord-stromal tumour==== | |||
The ISUP recommends:<ref name=pmid25025364>{{cite journal |author=Amin MB, Epstein JI, Ulbright TM, ''et al.'' |title=Best practices recommendations in the application of immunohistochemistry in urologic pathology: report from the international society of urological pathology consensus conference |journal=Am. J. Surg. Pathol. |volume=38 |issue=8 |pages=1017–22 |year=2014 |month=August |pmid=25025364 |doi=10.1097/PAS.0000000000000254 |url=}}</ref> | |||
*SALL4 +ve. | |||
*Alpha-inhibin -ve (+ve in [[SCST]]). | |||
*Calretinin -ve (+ve in SCST). | |||
Alternates for SALL4 are:<ref name=pmid25025364/> | |||
*OCT4 and GPC3. | |||
===Tabular summary of GCTs=== | ===Tabular summary of GCTs=== | ||