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Difference between revisions of "Malignant mesothelioma"
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| IHC = calretinin +ve, D2-40 +ve, CK5/6 +ve, WT-1 +ve, CK7 +ve, CEA -ve, TTF-1 -ve | | IHC = calretinin +ve, D2-40 +ve, CK5/6 +ve, WT-1 +ve, CK7 +ve, CEA -ve, TTF-1 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = p16 deletion | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
| Line 140: | Line 140: | ||
*Claudin-4. | *Claudin-4. | ||
**Mesothelioma may be focally positive.<ref name=pmid23775021>{{cite journal |author=Ohta Y, Sasaki Y, Saito M, ''et al.'' |title=Claudin-4 as a marker for distinguishing malignant mesothelioma from lung carcinoma and serous adenocarcinoma |journal=Int. J. Surg. Pathol. |volume=21 |issue=5 |pages=493–501 |year=2013 |month=October |pmid=23775021 |doi=10.1177/1066896913491320 |url=}}</ref> | **Mesothelioma may be focally positive.<ref name=pmid23775021>{{cite journal |author=Ohta Y, Sasaki Y, Saito M, ''et al.'' |title=Claudin-4 as a marker for distinguishing malignant mesothelioma from lung carcinoma and serous adenocarcinoma |journal=Int. J. Surg. Pathol. |volume=21 |issue=5 |pages=493–501 |year=2013 |month=October |pmid=23775021 |doi=10.1177/1066896913491320 |url=}}</ref> | ||
==Molecular== | |||
*p16 deletion by [[FISH]].<ref name=pmid24503757>{{cite journal |author=Hwang H, Tse C, Rodriguez S, Gown A, Churg A |title=p16 FISH deletion in surface epithelial mesothelial proliferations is predictive of underlying invasive mesothelioma |journal=Am. J. Surg. Pathol. |volume=38 |issue=5 |pages=681–8 |year=2014 |month=May |pmid=24503757 |doi=10.1097/PAS.0000000000000176 |url=}}</ref> | |||
Notes: | |||
*p16 IHC does ''not'' give the same result. | |||
*Sensitivity of p16 deletion is low. | |||
==See also== | ==See also== | ||