Difference between revisions of "Inflammatory bowel disease"

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#Basal inflammation, i.e. crypt base, plasmacytosis with severe chronic inflammation.
#Basal inflammation, i.e. crypt base, plasmacytosis with severe chronic inflammation.
#Crypt architectural abnormalities.
#Crypt architectural abnormalities.
#*Includes:
#*Atrophy = less glands ~ 3-4 glands/mm (normal = 7-8 glands/mm).
#**Atrophy = less glands ~ 3-4 glands/mm (normal = 7-8 glands/mm).
#*Branching = common (normal = very rare branching).
#**Branching = common (normal = very rare branching).
#*Distortion = bent glands, marked size variation (normal = "rack of test tubes").
#**Distortion = bent glands, marked size variation (normal = "rack of test tubes").
#Distal Paneth cell metaplasia.
#Distal Paneth cell metaplasia.
**Paneth cells should ''not'' be in the left colon<ref name=pmid11851832>{{cite journal |author=Tanaka M, Saito H, Kusumi T, ''et al'' |title=Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic inflammatory bowel disease |journal=J. Gastroenterol. Hepatol. |volume=16 |issue=12 |pages=1353–9 |year=2001 |month=December |pmid=11851832 |doi= |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2001&volume=16&issue=12&spage=1353}}</ref> - if you see 'em think of IBD and other long-standing injurious processes.
#*Paneth cells should ''not'' be in the left colon<ref name=pmid11851832>{{cite journal |author=Tanaka M, Saito H, Kusumi T, ''et al'' |title=Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic inflammatory bowel disease |journal=J. Gastroenterol. Hepatol. |volume=16 |issue=12 |pages=1353–9 |year=2001 |month=December |pmid=11851832 |doi= |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2001&volume=16&issue=12&spage=1353}}</ref> - if you see 'em think of IBD and other long-standing injurious processes.
**Some claim that (friendly right colonic) paneth cells and paneth cell metaplasia look quite different and can be distinguished.<ref name=pmid12655793>{{cite journal |author=Rubio CA, Nesi G |title=A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections |journal=In Vivo |volume=17 |issue=1 |pages=67–71 |year=2003 |pmid=12655793 |doi= |url=}}</ref>
#*Some claim that (friendly right colonic) paneth cells and paneth cell metaplasia look quite different and can be distinguished.<ref name=pmid12655793>{{cite journal |author=Rubio CA, Nesi G |title=A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections |journal=In Vivo |volume=17 |issue=1 |pages=67–71 |year=2003 |pmid=12655793 |doi= |url=}}</ref>


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Notes:  
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==Crohn's disease vs. ulcerative colitis==
==Crohn's disease vs. ulcerative colitis==
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