Difference between revisions of "Granular cell tumour"

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| Caption    = Granular cell tumour. [[H&E stain]].
| Caption    = Granular cell tumour. [[H&E stain]].
| Micro      = cells with abundant eosinophilic granular cytoplasm (granules ~ 1-3 micrometers, poorly demarcated on LM), +/-[[pseudoepitheliomatous hyperplasia]]  
| Micro      = cells with abundant eosinophilic granular cytoplasm (granules ~ 1-3 micrometers, poorly demarcated on LM), +/-[[pseudoepitheliomatous hyperplasia]]  
| Subtypes  =
| Subtypes  = benign (common), malignant (uncommon)
| LMDDx      = [[squamous cell carcinoma]], [[oncocytoma]], adjacent ulcer, [[xanthoma]], [[melanocytic nevus]] with neurotization  
| LMDDx      = [[squamous cell carcinoma]], [[oncocytoma]], adjacent ulcer, [[xanthoma]], [[melanocytic nevus]] with neurotization  
| Stains    = PAS +ve
| Stains    = PAS +ve
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| Rads      =
| Rads      =
| Endoscopy  =
| Endoscopy  =
| Prognosis  = usu. benign, may be malignant
| Prognosis  = usually good (benign)
| Other      =
| Other      =
| ClinDDx    =
| ClinDDx    = xanthoma, other [[skin]] lesions
}}
}}
The '''granular cell tumour''' is a rare histomorphologically distinctive neoplasm found at many sites. The classic location is the head and neck.
The '''granular cell tumour''' is a rare histomorphologically distinctive neoplasm found at many sites. The classic location is the [[head and neck pathology|head and neck]].


==General==
==General==
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***Gene implicated in ''[[Noonan syndrome]] 1''.
***Gene implicated in ''[[Noonan syndrome]] 1''.
*May mimic (well-differentiated) [[squamous cell carcinoma]] - histopathologically.
*May mimic (well-differentiated) [[squamous cell carcinoma]] - histopathologically.
**There is a well-described phenomenon called ''pseudoepitheliomatous hyperplasia''.<ref name=pmid16487362>{{cite journal |author=Abu-Eid R, Landini G |title=Morphometrical differences between pseudoepitheliomatous hyperplasia in granular cell tumours and squamous cell carcinomas |journal=Histopathology |volume=48 |issue=4 |pages=407–16 |year=2006 |month=March |pmid=16487362 |doi=10.1111/j.1365-2559.2006.02350.x |url=}}</ref>
**There is a well-described phenomenon called ''[[pseudoepitheliomatous hyperplasia]]''.<ref name=pmid16487362>{{cite journal |author=Abu-Eid R, Landini G |title=Morphometrical differences between pseudoepitheliomatous hyperplasia in granular cell tumours and squamous cell carcinomas |journal=Histopathology |volume=48 |issue=4 |pages=407–16 |year=2006 |month=March |pmid=16487362 |doi=10.1111/j.1365-2559.2006.02350.x |url=}}</ref>


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*[[Melanocytic nevus]] with neurotization.
*[[Melanocytic nevus]] with neurotization.
*[[Xanthoma]].
*[[Xanthoma]].
===Malignant features===
Features of malignancy (3 of 6 required):<ref name=pmid9669341>{{cite journal |author=Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG |title=Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation |journal=Am. J. Surg. Pathol. |volume=22 |issue=7 |pages=779–94 |year=1998 |month=July |pmid=9669341 |doi= |url=}}</ref>
*[[Necrosis]].
*Spindled tumour cells.
*Vesciular nuclei with large [[nucleoli]].
*Mitoses (>2/10 [[HPF]] at 200x).
*High [[NC ratio]].
*Pleomorphism.
Predictive of poor outcome:<ref name=pmid9669341/>
*Ki-67 >10%.


==Special stains==
==Special stains==
48,833

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