|
|
(8 intermediate revisions by the same user not shown) |
Line 1: |
Line 1: |
| '''Non-malignant skin disease''' is relatively common. The pathology may or may not be specific. Some diseases require clinical information to diagnose. | | '''Non-malignant skin disease''' is relatively common. The pathology may or may not be specific. Some diseases require clinical information to diagnose. |
|
| |
|
| An introduction to dermatopathology is in the ''[[dermatopathology]]'' article. [[Nevi]] (moles) and other melanocytic lesions are dealt with in the article ''[[melanocytic lesions]]''. Inflammatory skin conditions are dealt with in ''[[inflammatory skin disorders]]''. | | An introduction to dermatopathology is in the ''[[dermatopathology]]'' article. [[Nevi]] (moles) and other melanocytic lesions are dealt with in the article ''[[melanocytic lesions]]''. Inflammatory skin conditions are dealt with in ''[[inflammatory skin disorders]]''. |
Line 50: |
Line 50: |
| *[[Exocytosis]] - blood cell infiltrate the epidermis. | | *[[Exocytosis]] - blood cell infiltrate the epidermis. |
|
| |
|
| Images: | | ====Images==== |
| *[[WC]]:
| | <gallery> |
| **[http://commons.wikimedia.org/wiki/File:Dermatomycosis_-_intermed_mag.jpg Dermatomycosis - intermed. mag. (WC)].
| | Image:Dermatomycosis_-_intermed_mag.jpg | Dermatomycosis - intermed. mag. (WC) |
| **[http://commons.wikimedia.org/wiki/File:Dermatomycosis_-_high_mag.jpg Dermatomycosis - high mag. (WC)].
| | Image:Dermatomycosis_-_high_mag.jpg | Dermatomycosis - high mag. (WC) |
| **[http://commons.wikimedia.org/wiki/File:Dermatomycosis_-_gms_-_low_mag.jpg Dermatomycosis - GMS stain - low mag. (WC)].
| | Image:Dermatomycosis_-_gms_-_low_mag.jpg | Dermatomycosis - GMS stain - low mag. (WC) |
| **[http://commons.wikimedia.org/wiki/File:Dermatomycosis_-_gms_-_high_mag.jpg Dermatomycosis - GMS stain - high mag. (WC)].
| | Image:Dermatomycosis_-_gms_-_high_mag.jpg | Dermatomycosis - GMS stain - high mag. (WC) |
| *www:
| | </gallery> |
| **[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/tinea_pas.jpg Dermatophytosis (ucsf.edu)].<ref>URL: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/tinea.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/tinea.html]. Accessed on: 25 February 2013.</ref>
| | www: |
| | *[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/tinea_pas.jpg Dermatophytosis (ucsf.edu)].<ref>URL: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/tinea.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/tinea.html]. Accessed on: 25 February 2013.</ref> |
|
| |
|
| ===Stains=== | | ===Stains=== |
Line 240: |
Line 241: |
|
| |
|
| Notes: | | Notes: |
| *It differs from verruca vulgaris... (1) orthokeratosis, (2) flat surface and base. | | *It differs from [[verruca vulgaris]]... (1) orthokeratosis, (2) flat surface and base. |
|
| |
|
| Images: | | ====Images==== |
| | www: |
| *[http://www.fujita-hu.ac.jp/~tsutsumi/case/case180.htm Verruca plana - several images (fujita-hu.ac.jp)]. | | *[http://www.fujita-hu.ac.jp/~tsutsumi/case/case180.htm Verruca plana - several images (fujita-hu.ac.jp)]. |
| *[http://bg.convdocs.org/pars_docs/refs/55/54881/54881_html_m70d4f7e5.jpg Verruca plana (convdocs.org)].<ref>URL: [http://bg.convdocs.org/docs/index-54881.html?page=10 http://bg.convdocs.org/docs/index-54881.html?page=10]. Accessed on: 9 October 2013.</ref>
| |
| *[http://www.dermatopathonline.com/verruca%20plana2.html Verruca plana - several good images (dermatopathonline.com)]. | | *[http://www.dermatopathonline.com/verruca%20plana2.html Verruca plana - several good images (dermatopathonline.com)]. |
|
| |
|
Line 286: |
Line 287: |
|
| |
|
| ==Clear cell acanthoma== | | ==Clear cell acanthoma== |
| ===General===
| | {{Main|Clear cell acanthoma}} |
| *Benign.
| |
| *Elderly.
| |
| *Classically on the leg.<ref name=pmid18583817>{{Cite journal | last1 = Akin | first1 = FY. | last2 = Ertam | first2 = I. | last3 = Ceylan | first3 = C. | last4 = Kazandi | first4 = A. | last5 = Ozdemir | first5 = F. | title = Clear cell acanthoma: new observations on dermatoscopy. | journal = Indian J Dermatol Venereol Leprol | volume = 74 | issue = 3 | pages = 285-7 | month = | year = | doi = | PMID = 18583817 | URL = http://www.ijdvl.com/text.asp?2008/74/3/285/41396 }}</ref>
| |
| *Rare.
| |
| *Clinically not distinct.
| |
| **Suspected clinically in only ~3% of cases.<ref name=pmid20931670>{{Cite journal | last1 = Morrison | first1 = LK. | last2 = Duffey | first2 = M. | last3 = Janik | first3 = M. | last4 = Shamma | first4 = HN. | title = Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. | journal = Int J Dermatol | volume = 49 | issue = 9 | pages = 1008-11 | month = Sep | year = 2010 | doi = | PMID = 20931670 }}</ref>
| |
| | |
| ===Microscopic===
| |
| Features:<ref>URL: [http://www.drmihm.com/cases/case.cfm?CaseID=45 http://www.drmihm.com/cases/case.cfm?CaseID=45]. Accessed on: 7 February 2012.</ref>
| |
| *Psoriasiform pattern - epidermal thickening ([[acanthosis]]).
| |
| *Keratinocytes:
| |
| **Pale or light pink cytoplasm (when compared to surrounding non-lesional keratinocytes).
| |
| **Separated from one another (spongiosis).
| |
| *+/-Stratum corneum [[neutrophil]]s.
| |
| | |
| DDx:
| |
| *[[Psoriasis vulgaris]].
| |
| | |
| Images:
| |
| *[http://www.drmihm.com/cases/casefigure.cfm?figID=906&CaseID=45 CCA (drmihm.com)].
| |
| *[http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-327718365 CCA - low mag. (dermatlas.com)].
| |
| *[http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=546460717 CCA - high mag. (dermatlas.com)].
| |
|
| |
|
| ==Chondrodermatitis nodularis chronica helicis== | | ==Chondrodermatitis nodularis chronica helicis== |
Line 323: |
Line 302: |
| ===General=== | | ===General=== |
| *Benign. | | *Benign. |
| *Looks like zit. | | *Looks like a zit. |
|
| |
|
| ===Microscopic=== | | ===Microscopic=== |
Line 339: |
Line 318: |
| ==Lichenoid keratosis== | | ==Lichenoid keratosis== |
| *[[AKA]] ''lichen planus-like keratosis''. | | *[[AKA]] ''lichen planus-like keratosis''. |
| *[[AKA]] ''lichenoid keratosis''.
| | {{Main|Lichenoid keratosis}} |
| | |
| ===General===
| |
| *Caucasians - middle age or older.
| |
| *May be a variant of [[seborrheic keratosis]] (with marked inflammation).<ref name=Ref_Derm346>{{Ref Derm|346}}</ref>
| |
| | |
| Clinical DDx:<ref name=Ref_Derm346>{{Ref Derm|346}}</ref>
| |
| *[[Basal cell carcinoma]], [[squamous cell carcinoma of the skin]], melanocytic neoplasm.
| |
| | |
| ===Microscopic===
| |
| Features:<ref name=Ref_Derm347>{{Ref Derm|347}}</ref>
| |
| *Hyperkeratosis.
| |
| *Parakeratosis.
| |
| *Band of inflammatory cells at DE junction (lichenoid inflammation).
| |
| *Dead keratinocytes (Civatte bodies).
| |
| *Dermal melanophages.
| |
| | |
| DDx:
| |
| *[[Lichen planus]] - need clinical correlation (mucosal lesions).
| |
| *[[Drug reaction]].
| |
| *[[Cutaneous T-cell lymphoma]].
| |
| *Regressed melanocytic lesion, esp. [[malignant melanoma]].
| |
| *Lichenoid [[actinic keratosis]] - has atypical hyperchromatic basal cells - esp. at edge of lesion, usu. in the context of [[solar elastosis]].
| |
| | |
| Images:
| |
| *[http://www.dermpathexpert.com/id57.html Lichenoid keratosis (dermpathexpert.com)].
| |
| | |
| ===Sign out===
| |
| <pre>
| |
| SKIN LESION, MID-MIDDLE BACK, PUNCH BIOPSY:
| |
| - LICHENOID KERATOSIS.
| |
| </pre>
| |
| | |
| ====Incompletely excised====
| |
| <pre>
| |
| SKIN LESION, LEFT CHEST, PUNCH BIOPSY:
| |
| - LICHENOID KERATOSIS VERSUS ACTINIC KERATOSIS.
| |
| - NEGATIVE FOR BASAL CELL CARCINOMA.
| |
| - SEE COMMENT.
| |
| | |
| COMMENT:
| |
| No eosinophils are apparent. No melanocytic lesion is identified; however, excision of the
| |
| whole lesion to exclude a partially regressed melanocytic lesion is suggested.
| |
| </pre>
| |
|
| |
|
| ==Granuloma annulare== | | ==Granuloma annulare== |
Line 422: |
Line 358: |
| Note: | | Note: |
| *Several variants exist.<ref name=pmid18032900>{{Cite journal | last1 = Jacyk | first1 = WK. | last2 = Rütten | first2 = A. | last3 = Requena | first3 = L. | title = Fibrous papule of the face with granular cells. | journal = Dermatology | volume = 216 | issue = 1 | pages = 56-9 | month = | year = 2008 | doi = 10.1159/000109359 | PMID = 18032900 }}</ref> | | *Several variants exist.<ref name=pmid18032900>{{Cite journal | last1 = Jacyk | first1 = WK. | last2 = Rütten | first2 = A. | last3 = Requena | first3 = L. | title = Fibrous papule of the face with granular cells. | journal = Dermatology | volume = 216 | issue = 1 | pages = 56-9 | month = | year = 2008 | doi = 10.1159/000109359 | PMID = 18032900 }}</ref> |
| | |
| | ===Images=== |
| | *[http://www.dermaamin.com/site/histopathology-of-the-skin/58-f/1739-fibrous-papule-angiofibroma-.html Fibrous papule (dermaamin.com)]. |
|
| |
|
| ===Sign out=== | | ===Sign out=== |