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Angiomatoid fibrous histiocytoma (view source)
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'''Angiomatoid fibrous histiocytoma''' is a rare [[soft tissue lesion]] that is typically seen in children and young adults. | |||
==General== | |||
*Rarely metastasizes. | |||
*Children & young adults. | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP624-5>{{Ref WMSP|624-5}}</ref> | |||
*Cystic spaces with blood - simulates a vascular neoplasm.<ref name=pmid228836>{{Cite journal | last1 = Enzinger | first1 = FM. | title = Angiomatoid malignant fibrous histiocytoma: a distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. | journal = Cancer | volume = 44 | issue = 6 | pages = 2147-57 | month = Dec | year = 1979 | doi = | PMID = 228836 }}</ref> | |||
*Epithelioid to spindle cells. | |||
**May have a histiocytic appearance.<ref>URL: [http://dermatology.cdlib.org/1605/1_case_reports/4_09-00041/patrizi.html http://dermatology.cdlib.org/1605/1_case_reports/4_09-00041/patrizi.html]. Accessed on: 15 November 2011.</ref> | |||
*Inflammation. | |||
**Lymphoid cuff<ref name=pmid20154033/> - lymphocytes around periphery of lesion. | |||
*Hemorrhage. | |||
Note: | |||
*The first impression may be that it is [[granuloma|granulomatous inflammation]]; however, the cytoplasm doesn't fit (it isn't bubbly and it isn't sheet-like), and the nuclei aren't quite right (few footprint shaped nuclei). | |||
===Images=== | |||
<gallery> | |||
Image:Angiomatoid_fibrous_histiocytoma_-_intermed_mag.jpg | AFH - intermed. mag. (WC/Nephron) | |||
Image:Angiomatoid_fibrous_histiocytoma_-_high_mag.jpg | AFH - high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.sarcomaimages.com/index.php?v=Angiomatoid-Fibrous-Histiocytoma AFH (sarcomaimages.com)]. | |||
*[http://jcp.bmj.com/content/63/2/124/F1.large.jpg AFH (bmj.com)].<ref name=pmid20154033>{{Cite journal | last1 = Matsumura | first1 = T. | last2 = Yamaguchi | first2 = T. | last3 = Tochigi | first3 = N. | last4 = Wada | first4 = T. | last5 = Yamashita | first5 = T. | last6 = Hasegawa | first6 = T. | title = Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation. | journal = J Clin Pathol | volume = 63 | issue = 2 | pages = 124-8 | month = Feb | year = 2010 | doi = 10.1136/jcp.2009.072256 | PMID = 20154033 | url = http://jcp.bmj.com/content/63/2/124.full }} | |||
</ref> | |||
*[http://path.upmc.edu/cases/case512.html AFH - several images (upmc.edu)]. | |||
==IHC== | |||
Features:<ref name=Ref_WMSP624-5>{{Ref WMSP|624-5}}</ref> | |||
*CD68 +ve. | |||
*CD57 +ve. | |||
*Desmin +ve. | |||
*Vimentin +ve. | |||
==Molecular== | |||
AFH has recurrent [[translocations]]: | |||
*t(12;16) FUS/ATF1. | |||
*t(12;22) EWS/ATF1. | |||
==See also== | |||
*[[Soft tissue lesions]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Soft tissue lesions]] | |||
[[Category:Pediatric pathology]] | |||