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Difference between revisions of "Human papillomavirus-associated head and neck squamous cell carcinoma"
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Human papillomavirus-associated head and neck squamous cell carcinoma (view source)
Revision as of 20:43, 2 June 2014
, 20:43, 2 June 2014no edit summary
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==IHC== | ==IHC== | ||
*p16 +ve.<ref name=pmid21752613>{{Cite journal | last1 = Heath | first1 = S. | last2 = Willis | first2 = V. | last3 = Allan | first3 = K. | last4 = Purdie | first4 = K. | last5 = Harwood | first5 = C. | last6 = Shields | first6 = P. | last7 = Simcock | first7 = R. | last8 = Williams | first8 = T. | last9 = Gilbert | first9 = DC. | title = Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice. | journal = Clin Oncol (R Coll Radiol) | volume = 24 | issue = 1 | pages = e18-23 | month = Feb | year = 2012 | doi = 10.1016/j.clon.2011.05.007 | PMID = 21752613 }}</ref> | *p16 +ve.<ref name=pmid21752613>{{Cite journal | last1 = Heath | first1 = S. | last2 = Willis | first2 = V. | last3 = Allan | first3 = K. | last4 = Purdie | first4 = K. | last5 = Harwood | first5 = C. | last6 = Shields | first6 = P. | last7 = Simcock | first7 = R. | last8 = Williams | first8 = T. | last9 = Gilbert | first9 = DC. | title = Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice. | journal = Clin Oncol (R Coll Radiol) | volume = 24 | issue = 1 | pages = e18-23 | month = Feb | year = 2012 | doi = 10.1016/j.clon.2011.05.007 | PMID = 21752613 }}</ref> | ||
*EBV -ve. | |||
*CK5/6 +ve. | |||
*p63 +ve. | |||
==Molecular== | |||
*EBER -ve. | *EBER -ve. | ||
==Sign out== | |||
<pre> | |||
BASE OF LEFT TONSIL, BIOPSY: | |||
- INVASIVE SQUAMOUS CELL CARCINOMA, POORLY DIFFERENTIATED, SEE COMMENT. | |||
COMMENT: | |||
The tumour is p16 positive and EBV negative; this favours a HPV-associated | |||
squamous cell carcinoma. Clinical correlation is suggested. | |||
The tumour stains as follows: | |||
POSITIVE: p63, CK5/6, BCL2. | |||
NEGATIVE: LCA, EBV, synaptophysin, chromogranin, CD56. | |||
PROLIFERATION (Ki-67): 90% of tumour cells. | |||
</pre> | |||
==See also== | ==See also== | ||
*[[Head and neck pathology]]. | *[[Head and neck pathology]]. | ||