Difference between revisions of "Cartilage"

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Cartilage (view source)

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→‎Synovial chondromatosis
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==Synovial chondromatosis==
==Synovial chondromatosis==
*[[AKA]] ''synovial osteochondromatosis''.
*[[AKA]] ''synovial osteochondromatosis''.
===General===
{{Main|Synovial chondromatosis}}
*Benign.
**Malignant transformation rare <5%.<ref name=pmid17848703/>
*Classically location: knee.<ref name=pmid17848703>{{Cite journal  | last1 = Murphey | first1 = MD. | last2 = Vidal | first2 = JA. | last3 = Fanburg-Smith | first3 = JC. | last4 = Gajewski | first4 = DA. | title = Imaging of synovial chondromatosis with radiologic-pathologic correlation. | journal = Radiographics | volume = 27 | issue = 5 | pages = 1465-88 | month =  | year =  | doi = 10.1148/rg.275075116 | PMID = 17848703 | URL = http://radiographics.rsna.org/content/27/5/1465.long }}</ref>
**Hip next most common site.
*Usually adults.
*Prevalence: male > female.
 
Note:
*This is a clinicoradiologic diagnosis.
 
===Gross/radiology===
*Intraarticular calcifications.
*Diffuse involvement of the joint.
*+/-Loose bodies in the joint ([[AKA]] ''joint mice'').
 
Image:
*[http://commons.wikimedia.org/wiki/File:ChondromatoseCoude.jpg Synovial chondromatosis (WC)].
*[http://radiographics.rsna.org/content/27/5/1465/F26.expansion.html SC - gross (rsna.org)].
 
===Microscopic===
Features:<ref name=pmid17848703/>
*[[Hyaline cartilage]] +/- lobular surface.
**+/-Lacunae with binucleate cells.
**+/-Nuclear atypia - moderate to severe.<ref>URL: [http://www.webpathology.com/image.asp?n=3&Case=369 http://www.webpathology.com/image.asp?n=3&Case=369]. Accessed on: 10 December 2012.</ref>
*+/-Synovial hyperplasia - ribbon like tissue with an epithelium that has eosinophilic cytoplasm.
*[[Bone]].
 
DDx:
*[[Chondrosarcoma]].
*[[Osteoarthritis]].
 
====Images====
www:
*[http://radiographics.rsna.org/content/27/5/1465.long Synovial chondromatosis (rsna.org)].
*[http://radiographics.rsna.org/content/27/5/1465/F45.expansion.html Synovial chondromatosis - low mag. (rsna.org)].
*[http://www.webpathology.com/image.asp?n=1&Case=369 Synovial chondromatosis (webpathology.com)].
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051128/figure/F0006/ Loose body with fibrotic synovial membrane (nih.gov)].
 
===Sign out===
<pre>
LOOSE BODIES, RIGHT ELBOW, REMOVAL:
- FRAGMENTS OF BONE WITH CARTILAGE AND SYNOVIAL TISSUE COMPATIBLE WITH LOOSE BODIES.
</pre>
 
<pre>
TISSUE, CAPSULE LEFT ELBOW, REMOVAL:
- DEGENERATIVE JOINT DISEASE.
- SYNOVIAL HYPERPLASIA WITHOUT SIGNIFICANT INFLAMMATION.
- ROUND BODIES CONSISTING OF BENIGN BONE WITH A FATTY MARROW, AND FIBROUS
  AND CARTILAGINOUS SURFACE, COMPATIBLE WITH LOOSE BODIES.
- NEGATIVE FOR MALIGNANCY.
</pre>
 
<pre>
LOOSE BODY, LEFT KNEE, REMOVAL:
- BENIGN BONE WITH FIBROTIC SYNOVIAL MEMBRANE, CONSISTENT WITH LOOSE BODY.
</pre>
 
====Micro====
The sections show multiple fragments of tissue consisting of bone covered by hyaline cartilage and associated with synovial hyperplasia.
 
There is no appreciable nuclear atypia or mitotic activity.


=See also=
=See also=
Michael
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