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'''Cystic medial degeneration''' (abbreviated '''CMD'''), also '''cystic medial necrosis''',<ref>URL: [http://emedicine.medscape.com/article/756835-overview http://emedicine.medscape.com/article/756835-overview]. Accessed on: 12 August 2010.</ref> is vascular pathology of the large [[blood vessel]]s suggestive of an underlying [[connective tissue disorder]]. | |||
==General== | |||
*Nonspecific finding - may be seen in a number of conditions. | |||
Note about ''cystic medial necrosis'': | |||
*Often ''not'' cystic and ''not'' necrotic. | |||
==Microscopic== | |||
Features:<ref>URL: [http://emedicine.medscape.com/article/756835-overview http://emedicine.medscape.com/article/756835-overview]. Accessed on: 12 August 2010.</ref><ref name=pmid17620463>{{cite journal |author=Ha HI, Seo JB, Lee SH, ''et al.'' |title=Imaging of Marfan syndrome: multisystemic manifestations |journal=Radiographics |volume=27 |issue=4 |pages=989–1004 |year=2007 |pmid=17620463 |doi=10.1148/rg.274065171 |url=http://radiographics.rsna.org/content/27/4/989.full}}</ref> | |||
*Basophilic ground substance in the media (seen on Movat's [[stain]]). | |||
*Disruption of the elastic lamina (seen on elastic trichrome stain). | |||
*+/-Focal necrosis. | |||
===Images=== | |||
<gallery> | |||
Image:Cystic_medial_degeneration_-_low_mag.jpg | Cystic medial degeneration - low mag. (WC/Nephron) | |||
Image:Cystic_medial_degeneration_-_high_mag.jpg | Cystic medial degeneration - high mag. (WC/Nephron) | |||
Image:Cystic_medial_degeneration_-_movat_-_low_mag.jpg | Cystic medial degeneration - movat - low mag. (WC/Nephron) | |||
Image:Cystic_medial_degeneration_-_movat_-_intermed_mag.jpg | Cystic medial degeneration - movat - intermed. mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://radiographics.rsna.org/content/27/4/989.full Marfan's syndrome (radiographics.rsna.org)]. | |||
==Stains== | |||
*Elastin stains (e.g. [[elastic trichrome stain]]) - disruption of the elastic lamina. | |||
*[[Movat's stain]] - basophilic ground substance in the media. | |||
==See also== | |||
*[[Vascular disease]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Vascular disease]] | |||