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Difference between revisions of "Serous tubal intraepithelial carcinoma"
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Serous tubal intraepithelial carcinoma (view source)
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'''Serous tubal intraepithelial carcinoma''', abbreviated '''STIC'''<ref name=pmid21989347>{{Cite journal | last1 = Visvanathan | first1 = K. | last2 = Vang | first2 = R. | last3 = Shaw | first3 = P. | last4 = Gross | first4 = A. | last5 = Soslow | first5 = R. | last6 = Parkash | first6 = V. | last7 = Shih | first7 = IeM. | last8 = Kurman | first8 = RJ. | title = Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1766-75 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e31822f58bc | PMID = 21989347 }}</ref> (pronounced ''stick''), is considered to be the precursor of [[serous carcinoma]]. | |||
It is also known as '''tubal intraepithelial carcinoma'''. | |||
==General== | |||
*Considered the precursor lesion for tubal [[serous carcinoma]].<ref name=pmid17117391>{{Cite journal | last1 = Lee | first1 = Y. | last2 = Miron | first2 = A. | last3 = Drapkin | first3 = R. | last4 = Nucci | first4 = MR. | last5 = Medeiros | first5 = F. | last6 = Saleemuddin | first6 = A. | last7 = Garber | first7 = J. | last8 = Birch | first8 = C. | last9 = Mou | first9 = H. | title = A candidate precursor to serous carcinoma that originates in the distal fallopian tube. | journal = J Pathol | volume = 211 | issue = 1 | pages = 26-35 | month = Jan | year = 2007 | doi = 10.1002/path.2091 | PMID = 17117391 }}</ref> | |||
==Gross== | |||
*Not apparent on gross. | |||
*Usually at the fimbriated end of the tube. | |||
==Microscopic== | |||
Features:<ref name=pmid20228782/> | |||
*Discrete papillary growth - low power. | |||
*Formal criteria - need 3 or more: | |||
*#Atypical chromatin pattern. | |||
*#Nuclear enlargement. | |||
*#Nuclear pleomorphism. | |||
*#Nuclear moulding. | |||
*#Loss of nuclear polarity ''or'' epithelial stratification. | |||
===Images=== | |||
*[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201060f1.html#figure-title STIC (nature.com)].<ref name=pmid20228782>{{Cite journal | last1 = Sehdev | first1 = AS. | last2 = Kurman | first2 = RJ. | last3 = Kuhn | first3 = E. | last4 = Shih | first4 = IeM. | title = Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 844-55 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.60 | PMID = 20228782 }}</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F3/ STIC - schematic (nih.gov)].<ref name=pmid21683865>{{Cite journal | last1 = Kurman | first1 = RJ. | last2 = Shih | first2 = IeM. | title = Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm. | journal = Hum Pathol | volume = 42 | issue = 7 | pages = 918-31 | month = Jul | year = 2011 | doi = 10.1016/j.humpath.2011.03.003 | PMID = 21683865 }}</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F6/ STIC and STIL with p53 stain (nih.gov)].<ref name=pmid21683865/> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148026/figure/F5/ STIC - p53 stain (nih.gov)].<ref name=pmid21683865/> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860809/figure/fig1/ Small STIC - H&E and p53 (nih.gov)].<ref name=pmid20445756>{{Cite journal | last1 = Gross | first1 = AL. | last2 = Kurman | first2 = RJ. | last3 = Vang | first3 = R. | last4 = Shih | first4 = IeM. | last5 = Visvanathan | first5 = K. | title = Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics. | journal = J Oncol | volume = 2010 | issue = | pages = 126295 | month = | year = 2010 | doi = 10.1155/2010/126295 | PMID = 20445756 }}</ref> | |||
*[http://www.ovariancancerprevention.org/wp-content/uploads/2010/10/apotosis-and-mitosis-in-STIC.jpg STIC - high mag. (ovariancancerprevention.org)].<ref>URL: [http://www.ovariancancerprevention.org/?page_id=191 http://www.ovariancancerprevention.org/?page_id=191]. Accessed on: 13 May 2014.</ref> | |||
*[http://www.ovariancancerprevention.org/wp-content/uploads/2010/10/STIC-junction-HM.jpg STIC & benign - high mag. (ovariancancerprevention.org)]. | |||
==IHC== | |||
Features:<ref name=pmid21989347/> | |||
*p53 +ve. | |||
*Ki-67 +ve. | |||
*p16 +ve.<ref name=pmid20228782/> | |||
==See also== | |||
*[[Uterine tubes]]. | |||
==References== | |||
{{Reflist|2}} | |||
==External links== | |||
*[http://www.ovariancancerprevention.org/?page_id=160 STIC training set (ovariancancerprevention.org)]. | |||
[[Category:Uterine tubes]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||