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Inverted urothelial papilloma (view source)
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'''Inverted urothelial papilloma''', also '''inverted papilloma''', is a benign [[urothelium|urothelial]] lesion that may be confused with [[urothelial carcinoma]]. | |||
==General== | |||
*May be confused with papillary urothelial carcinoma with an inverted growth pattern. | |||
==Microscopic== | |||
Features: | |||
*Like papillomas... but grow downward.<ref name=Ref_WMSP310>{{Ref WMSP|310}}</ref> | |||
*According to THvdK,<ref>THvdK. 21 June 2010.</ref> ''inverted papillomas'' '''never''' have an exophytic component; if an exophytic component is present it is urothelial carcinoma. This is disputed by one paper from Mexico that examines two cases.<ref name=pmid19433293>{{cite journal |author=Albores-Saavedra J, Chable-Montero F, Hernández-Rodríguez OX, Montante-Montes de Oca D, Angeles-Angeles A |title=Inverted urothelial papilloma of the urinary bladder with focal papillary pattern: a previously undescribed feature |journal=Ann Diagn Pathol |volume=13 |issue=3 |pages=158–61 |year=2009 |month=June |pmid=19433293 |doi=10.1016/j.anndiagpath.2009.02.009 |url=}}</ref> | |||
*Nests have peripheral palisading of nuclei - '''important'''. | |||
DDx: | |||
*[[Low grade papillary urothelial carcinoma]] with an inverted growth pattern. | |||
===Images=== | |||
<gallery> | |||
Image:Inverted_papilloma_high_mag.jpg | Inverted papilloma - high mag. (WC/Nephron) | |||
Image:Inverted_papilloma_intermed_mag.jpg | Inverted papilloma - intermed. mag. (WC/Nephron) | |||
</gallery> | |||
==IHC== | |||
May be useful versus inverted growth pattern UCC:<ref name=pmid18043040>{{Cite journal | last1 = Jones | first1 = TD. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Eble | first4 = JN. | last5 = Sung | first5 = MT. | last6 = MacLennan | first6 = GT. | last7 = Montironi | first7 = R. | last8 = Tan | first8 = PH. | last9 = Zheng | first9 = S. | title = Urothelial carcinoma with an inverted growth pattern can be distinguished from inverted papilloma by fluorescence in situ hybridization, immunohistochemistry, and morphologic analysis. | journal = Am J Surg Pathol | volume = 31 | issue = 12 | pages = 1861-7 | month = Dec | year = 2007 | doi = 10.1097/PAS.0b013e318060cb9d | PMID = 18043040 }}</ref> | |||
*Ki-67 -ve. | |||
*CK20 -ve. | |||
*p53 -ve (rarely +ve). | |||
==See also== | |||
*[[Urothelium]]. | |||
*[[Cystitis cystica]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Urothelium]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||