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Renal cell carcinoma with rhabdoid morphology (view source)
Revision as of 20:04, 4 April 2019
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[[Image: Renal cell carcinoma with rhabdoid change -- intermed mag.jpg|thumb|300px|[[Micrograph]] showing rhabdoid change in a renal cell carcinoma. [[H&E stain]].]] | |||
'''Renal cell carcinoma with rhabdoid morphology''' is an uncommon finding with a poor prognosis. It is also known as '''renal cell carcinoma with rhabdoid change'''. | '''Renal cell carcinoma with rhabdoid morphology''' is an uncommon finding with a poor prognosis. It is also known as '''renal cell carcinoma with rhabdoid change'''. | ||
It should '''not''' be confused with [[renal rhabdoid tumour]]. | |||
==General== | ==General== | ||
*Not recognized as a distinct entity.<ref name=pmid21665507>{{Cite journal | last1 = Chapman-Fredricks | first1 = JR. | last2 = Herrera | first2 = L. | last3 = Bracho | first3 = J. | last4 = Gomez-Fernandez | first4 = C. | last5 = Leveillee | first5 = R. | last6 = Rey | first6 = L. | last7 = Jorda | first7 = M. | title = Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma. | journal = Ann Diagn Pathol | volume = 15 | issue = 5 | pages = 333-7 | month = Oct | year = 2011 | doi = 10.1016/j.anndiagpath.2011.03.002 | PMID = 21665507 }}</ref> | *Not recognized as a distinct entity.<ref name=pmid21665507>{{Cite journal | last1 = Chapman-Fredricks | first1 = JR. | last2 = Herrera | first2 = L. | last3 = Bracho | first3 = J. | last4 = Gomez-Fernandez | first4 = C. | last5 = Leveillee | first5 = R. | last6 = Rey | first6 = L. | last7 = Jorda | first7 = M. | title = Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma. | journal = Ann Diagn Pathol | volume = 15 | issue = 5 | pages = 333-7 | month = Oct | year = 2011 | doi = 10.1016/j.anndiagpath.2011.03.002 | PMID = 21665507 }}</ref> | ||
*[[ISUP nucleolar grade]] 4 by definition. | |||
*May be seen in [[ALK translocation renal cell carcinoma]].<ref name=pmid26017874>{{Cite journal | last1 = Kuroda | first1 = N. | last2 = Karashima | first2 = T. | last3 = Inoue | first3 = K. | last4 = Kasajima | first4 = A. | last5 = Ohe | first5 = C. | last6 = Kawakami | first6 = F. | last7 = Mikami | first7 = S. | last8 = Matsuura | first8 = K. | last9 = Moriyama | first9 = M. | title = Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects. | journal = Pol J Pathol | volume = 66 | issue = 1 | pages = 3-8 | month = Mar | year = 2015 | doi = | PMID = 26017874 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*[[Rhabdoid cells]]: | *[[Rhabdoid cells]]: | ||
**Eccentrically placed large round nuclei with | **Eccentrically placed large round nuclei with abundant eosinophilic cytoplasm. | ||
** | **+/-Very prominent [[nucleolus]]. | ||
Notes: | Notes: | ||
*May be multinucleated. | *May be multinucleated. | ||
===Images=== | |||
<gallery> | |||
Image: Renal cell carcinoma with rhabdoid change -- low mag.jpg | RCC with RC - low mag. | |||
Image: Renal cell carcinoma with rhabdoid change -- intermed mag.jpg | RCC with RC - intermed. mag. | |||
Image: Renal cell carcinoma with rhabdoid change -- high mag.jpg | RCC with RC - high mag. | |||
Image: Renal cell carcinoma with rhabdoid change -- very high mag.jpg | RCC with RC - very high mag. | |||
Image: Renal cell carcinoma with rhabdoid change - alt -- very high mag.jpg | RCC with RC - very high mag. | |||
</gallery> | |||
==IHC== | ==IHC== | ||
| Line 20: | Line 34: | ||
*Desmin -ve (23 of 23 cases). | *Desmin -ve (23 of 23 cases). | ||
*SMA -ve (~5% of cases). | *SMA -ve (~5% of cases). | ||
==Sign out== | |||
<pre> | |||
MASS, RIGHT KIDNEY, RADICAL NEPHRECTOMY: | |||
- CLEAR CELL RENAL CELL CARCINOMA, ISUP NUCLEOLAR GRADE 4, pT1b, pNX. | |||
-- RHABDOID CHANGE PRESENT, SEE COMMENT. | |||
-- MARGINS NEGATIVE FOR MALIGNANCY. | |||
-- PLEASE SEE TUMOUR SUMMARY. | |||
COMMENT: | |||
Rhabdoid change is considered by some to be analogous to sarcomatoid | |||
change.[1] The rhabdoid change in this case represents approximately | |||
35% of the tumour, and has ISUP nucleolar grade 4 nuclear features. | |||
1. Ann Diagn Pathol. 2011 Oct;15(5):333-7. | |||
</pre> | |||
==See also== | ==See also== | ||
*[[Renal cell carcinoma]]. | *[[Renal cell carcinoma]]. | ||
*[[Renal cell carcinoma with sarcomatoid differentiation]]. | |||
*[[Rhabdoid]]. | *[[Rhabdoid]]. | ||
*[[ISUP nucleolar grade]]. | |||
==References== | ==References== | ||