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Follicular dendritic cell sarcoma (view source)
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'''Follicular dendritic cell sarcoma''', abbreviated '''FDCS''', is a very rare [[malignant]] tumour. | |||
It is also known as '''follicular dendritic cell tumour''' (abbreviated '''FDCT'''.<ref name=pmid17515347>{{Cite journal | last1 = Leipsic | first1 = JA. | last2 = McAdams | first2 = HP. | last3 = Sporn | first3 = TA. | title = Follicular dendritic cell sarcoma of the mediastinum. | journal = AJR Am J Roentgenol | volume = 188 | issue = 6 | pages = W554-6 | month = Jun | year = 2007 | doi = 10.2214/AJR.04.1530 | PMID = 17515347 }}</ref> | |||
Other possible names are ''dendritic reticulum cell sarcoma'', (???) ''follicular dendritic cell neoplasm''. (???) | |||
==General== | |||
*Very rare. | |||
*Behave like a low-grade sarcoma.<ref name=pmid9606805>{{Cite journal | last1 = Perez-Ordoñez | first1 = B. | last2 = Rosai | first2 = J. | title = Follicular dendritic cell tumor: review of the entity. | journal = Semin Diagn Pathol | volume = 15 | issue = 2 | pages = 144-54 | month = May | year = 1998 | doi = | PMID = 9606805 }}</ref> | |||
*Reported association with [[Castleman disease]] (hyaline-vascular type).<ref name=pmid9606805/> | |||
==Microscopic== | |||
Features:<ref name=pmid9606805/> | |||
*Oval or spindle-shaped cellular & nuclear morphology. | |||
*Variable architecture (sheets, fascicles, whorles, storiform pattern). | |||
*Nuclei: | |||
**Small nucleoli. | |||
**Clear or dispersed chromatin. | |||
*Multinucleated cells. | |||
*Interspersed small lymphocytes - '''distinctive feature'''. | |||
*+/-Necrosis. | |||
*+/-Marked nuclear atypia. | |||
*+/-Abundant mitoses. | |||
DDx: | |||
*[[Histiocytic sarcoma]].<ref name=pmid17324277>{{Cite journal | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue = | pages = 7 | month = | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 | url = http://www.diagnosticpathology.org/content/2/1/7 }}</ref> | |||
*[[Spindle cell lesions]]. | |||
===Images=== | |||
*[http://www.ajronline.org/content/188/6/W554/F7.expansion FDCS (ajronline.org)].<ref name=pmid17515347/> | |||
*[http://www.webpathology.com/image.asp?case=391&n=1 DRCS (webpathology.com)]. | |||
*[http://path.upmc.edu/cases/case55/dx.html FDCT - several crappy images (upmc.edu)]. | |||
*[http://path.upmc.edu/cases/case399.html FDCS - several images (upmc.edu)]. | |||
==IHC== | |||
Features:<ref name=pmid9606805/> | |||
*CD21 +ve. | |||
*CD35 +ve. | |||
*Ki-M4p +ve | |||
*Ki-FDRC1p +ve. | |||
*Vimentin +ve. | |||
*S-100 +ve/-ve. | |||
*Muscle-specific actin +ve/-ve. | |||
*EMA +ve/-ve. | |||
==See also== | |||
*[[Spleen]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Spleen]] | |||