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Adenocarcinoma of the duodenum (view source)
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'''Adenocarcinoma of the duodenum''' is an uncommon epithelial derived malignancy of the [[duodenum]]. It is frequently associated with [[familial adenomatous polyposis]]. | |||
It is also known as '''duodenal adenocarcinoma''', '''duodenal carcinoma''' and '''carcinoma of the duodenum'''. | |||
==General== | |||
*Duodenum - most common site in [[small bowel]]. | |||
**[[Ampulla of Vater]] most common site in the duodenum - see ''[[ampullary carcinoma]]''. | |||
Risk factors: | |||
*[[Crohn's disease]]. | |||
*[[Celiac sprue]]. | |||
*[[Familial adenomatous polyposis]] (FAP). | |||
*[[HNPCC]]. | |||
*[[Peutz-Jeghers syndrome]]. | |||
==Gross== | |||
*Mass ulcerating or exophytic. | |||
Image: | |||
<gallery> | |||
Image:Duodenal adenocarcinoma.png | Duodenal adenocarcinoma - endoscopy. (WC/Samir) | |||
</gallery> | |||
==Microscopic== | |||
Features: | |||
*Similar to large bowel adenocarcinomas - see ''[[colorectal tumours]]'' article. | |||
**May be similar to gastric adenocarcinomas (gastric-type adenocarcinoma).<ref>{{Cite journal | last1 = Kushima | first1 = R. | last2 = Stolte | first2 = M. | last3 = Dirks | first3 = K. | last4 = Vieth | first4 = M. | last5 = Okabe | first5 = H. | last6 = Borchard | first6 = F. | last7 = Hattori | first7 = T. | title = Gastric-type adenocarcinoma of the duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner's glands. | journal = Virchows Arch | volume = 440 | issue = 6 | pages = 655-9 | month = Jun | year = 2002 | doi = 10.1007/s00428-002-0615-z | PMID = 12070607 }} | |||
</ref> | |||
DDx: | |||
*[[Ampullary carcinoma]]. | |||
==IHC== | |||
*SMAD4 -ve/+ve.<ref name=pmid15157044>{{Cite journal | last1 = Bläker | first1 = H. | last2 = Aulmann | first2 = S. | last3 = Helmchen | first3 = B. | last4 = Otto | first4 = HF. | last5 = Rieker | first5 = RJ. | last6 = Penzel | first6 = R. | title = Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings. | journal = Pathol Res Pract | volume = 200 | issue = 1 | pages = 1-7 | month = | year = 2004 | doi = | PMID = 15157044 }}</ref> | |||
==See also== | |||
*[[Duodenum]]. | |||
*[[Adenocarcinoma]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Duodenum]] | |||
[[Category:Diagnosis]] | |||