Difference between revisions of "Duodenum"

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Duodenum (view source)

Revision as of 00:14, 23 April 2014

1,702 bytes removed ,  00:14, 23 April 2014
→‎Adenocarcinoma of the duodenum: split out
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*[[AKA]] ''duodenal adenocarcinoma''.
*[[AKA]] ''duodenal adenocarcinoma''.
*[[AKA]] ''duodenal carcinoma''.
*[[AKA]] ''duodenal carcinoma''.
 
{{Main|Adenocarcinoma of the duodenum}}
===General===
*Duodenum - most common site in small bowel.
**[[Ampulla of Vater]] most common site in the duodenum - see ''[[ampullary carcinoma]]''.
 
Risk factors:
*[[Crohn's disease]].
*[[Celiac sprue]].
*[[Familial adenomatous polyposis]] (FAP).
*[[HNPCC]].
*[[Peutz-Jeghers syndrome]].
 
===Gross===
*Mass ulcerating or exophytic.
 
Image:
<gallery>
Image:Duodenal adenocarcinoma.png | Duodenal adenocarcinoma - endoscopy. (WC/Samir)
</gallery>
 
===Microscopic===
Features:
*Similar to large bowel adenocarcinomas - see ''[[colorectal tumours]]'' article.
**May be similar to gastric adenocarcinomas (gastric-type adenocarcinoma).<ref>{{Cite journal  | last1 = Kushima | first1 = R. | last2 = Stolte | first2 = M. | last3 = Dirks | first3 = K. | last4 = Vieth | first4 = M. | last5 = Okabe | first5 = H. | last6 = Borchard | first6 = F. | last7 = Hattori | first7 = T. | title = Gastric-type adenocarcinoma of the duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner's glands. | journal = Virchows Arch | volume = 440 | issue = 6 | pages = 655-9 | month = Jun | year = 2002 | doi = 10.1007/s00428-002-0615-z | PMID = 12070607 }}
</ref>
 
DDx:
*[[Ampullary carcinoma]].
 
===IHC===
*SMAD4 -ve/+ve.<ref name=pmid15157044>{{Cite journal  | last1 = Bläker | first1 = H. | last2 = Aulmann | first2 = S. | last3 = Helmchen | first3 = B. | last4 = Otto | first4 = HF. | last5 = Rieker | first5 = RJ. | last6 = Penzel | first6 = R. | title = Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings. | journal = Pathol Res Pract | volume = 200 | issue = 1 | pages = 1-7 | month =  | year = 2004 | doi =  | PMID = 15157044 }}</ref>


==Duodenal neuroendocrine tumour==
==Duodenal neuroendocrine tumour==
Michael
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