Difference between revisions of "An introduction to gynecologic pathology"

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An introduction to gynecologic pathology (view source)

Revision as of 01:08, 19 April 2014

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→‎Mesonephric duct remnant: split out
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*[[AKA]] ''Wolffian duct remnant''.
*[[AKA]] ''Wolffian duct remnant''.
*[[AKA]] ''Gartner duct''.<ref>URL: [http://webpathology.com/image.asp?n=3&Case=540 http://webpathology.com/image.asp?n=3&Case=540]. Accessed on: 22 October 2012.</ref>  
*[[AKA]] ''Gartner duct''.<ref>URL: [http://webpathology.com/image.asp?n=3&Case=540 http://webpathology.com/image.asp?n=3&Case=540]. Accessed on: 22 October 2012.</ref>  
 
{{Main|Mesonephric duct remnant}}
===General===
Epidemiology:
*Embryological remnant - benign.
**Wolffian duct = precursor of male reproductive tract.<ref name=pmid16567946>{{cite journal |author=Hannema SE, Print CG, Charnock-Jones DS, Coleman N, Hughes IA |title=Changes in gene expression during Wolffian duct development |journal=Horm. Res. |volume=65 |issue=4 |pages=200–9 |year=2006 |pmid=16567946 |doi=10.1159/000092408 |url=}}</ref>
 
Notes:
*This is ''not'' a finding that is reported.  The importance of this finding is knowing it isn't something neoplastic.
*Lame way of remember the synonyms ''Gartner, Mesonephric, and Wolffian'': ''GMW''... it is trying to be a ''BMW'' but in ''g''irls.
 
===Gross===
*Classically anterior-lateral wall of the [[vagina]].<ref name=Ref_GP97>{{Ref GP|97}}</ref>
 
Note:
*Same location as Muellerian cyst.
===Microscopic===
Features:<ref>Sternberg SE. Histology for Pathologists. 2nd Ed. P.893.</ref>
*Small duct -- typically ~50-100 micrometres in diameter.
**Duct lined by cuboidal cells with moderate eosinophilic cytoplasm.
DDx:
*Muellerian cyst - most common vaginal cyst.<ref name=Ref_GP97>{{Ref GP|97}}</ref>
*[[Vaginal inclusion cyst]].
*[[Cervical adenocarcinoma]], not otherwise specified.
*[[Minimal deviation adenocarcinoma of the uterine cervix]].
*[[Mesonephric adenocarcinoma]] - has cellular atypia.
*[[Wolffian duct hyperplasia]].
 
Images:
*[http://www.webpathology.com/image.asp?case=550&n=1 Mesonephric duct remnant - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=2&Case=550 Mesonephric duct remnant - high mag. (webpathology.com)].
 
===IHC===
Features:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref>
*CD10 +ve.
*CK7 +ve.
*PAX2 +ve (nuclear - strong & diffuse).<ref name=pmid20061933>{{Cite journal  | last1 = Rabban | first1 = JT. | last2 = McAlhany | first2 = S. | last3 = Lerwill | first3 = MF. | last4 = Grenert | first4 = JP. | last5 = Zaloudek | first5 = CJ. | title = PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma. | journal = Am J Surg Pathol | volume = 34 | issue = 2 | pages = 137-46 | month = Feb | year = 2010 | doi = 10.1097/PAS.0b013e3181c89c98 | PMID = 20061933 }}</ref>
**Cancers often lose staining.


==Walthard cell rest==
==Walthard cell rest==
Michael
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