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Difference between revisions of "Mesonephric duct remnant"
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'''Mesonephric duct remnant''', also '''Wolffian duct remnant''' and '''Gartner duct''', a benign embryological remanant that is usually ignored. | |||
==General== | |||
Epidemiology: | |||
*Embryological remnant - benign. | |||
**Wolffian duct = precursor of male reproductive tract.<ref name=pmid16567946>{{cite journal |author=Hannema SE, Print CG, Charnock-Jones DS, Coleman N, Hughes IA |title=Changes in gene expression during Wolffian duct development |journal=Horm. Res. |volume=65 |issue=4 |pages=200–9 |year=2006 |pmid=16567946 |doi=10.1159/000092408 |url=}}</ref> | |||
Notes: | |||
*This is ''not'' a finding that is reported. The importance of this finding is knowing it isn't something neoplastic. | |||
*Lame way of remember the synonyms ''Gartner, Mesonephric, and Wolffian'': ''GMW''... it is trying to be a ''BMW'' but in ''g''irls. | |||
==Gross== | |||
*Classically anterior-lateral wall of the [[vagina]].<ref name=Ref_GP97>{{Ref GP|97}}</ref> | |||
Note: | |||
*Same location as Muellerian cyst. | |||
==Microscopic== | |||
Features:<ref>Sternberg SE. Histology for Pathologists. 2nd Ed. P.893.</ref> | |||
*Small duct -- typically ~50-100 micrometres in diameter. | |||
**Duct lined by cuboidal cells with moderate eosinophilic cytoplasm. | |||
DDx: | |||
*Muellerian cyst - most common vaginal cyst.<ref name=Ref_GP97>{{Ref GP|97}}</ref> | |||
*[[Vaginal inclusion cyst]]. | |||
*[[Cervical adenocarcinoma]], not otherwise specified. | |||
*[[Minimal deviation adenocarcinoma of the uterine cervix]]. | |||
*[[Mesonephric adenocarcinoma]] - has cellular atypia. | |||
*[[Wolffian duct hyperplasia]]. | |||
Images: | |||
*[http://www.webpathology.com/image.asp?case=550&n=1 Mesonephric duct remnant - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?n=2&Case=550 Mesonephric duct remnant - high mag. (webpathology.com)]. | |||
==IHC== | |||
Features:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref> | |||
*CD10 +ve. | |||
*CK7 +ve. | |||
*PAX2 +ve (nuclear - strong & diffuse).<ref name=pmid20061933>{{Cite journal | last1 = Rabban | first1 = JT. | last2 = McAlhany | first2 = S. | last3 = Lerwill | first3 = MF. | last4 = Grenert | first4 = JP. | last5 = Zaloudek | first5 = CJ. | title = PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma. | journal = Am J Surg Pathol | volume = 34 | issue = 2 | pages = 137-46 | month = Feb | year = 2010 | doi = 10.1097/PAS.0b013e3181c89c98 | PMID = 20061933 }}</ref> | |||
**Cancers often lose staining. | |||
==See also== | |||
*[[Gynecologic pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Gynecologic pathology]] | |||