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Epithelioid hemangioendothelioma (view source)
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'''Epithelioid hemangioendothelioma''' is rare malignant [[vascular tumours|vascular tumour]]. | |||
It should '''not''' be confused with ''[[epithelioid hemangioma]]''. | |||
==General== | |||
*Malignant.<ref name=Ref_WMSP603>{{Ref WMSP|603}}</ref> | |||
*Adults - wide age range. | |||
*Associated with oral contraceptives, vinyl chloride.<ref name=pmid20165548/> | |||
==Microscopic== | |||
Features:<ref name=pmid20165548>{{Cite journal | last1 = Gupta | first1 = R. | last2 = Mathur | first2 = SR. | last3 = Gupta | first3 = SD. | last4 = Durgapal | first4 = P. | last5 = Iyer | first5 = VK. | last6 = Das | first6 = CJ. | last7 = Shalimar | first7 = SK. | last8 = Acharya | first8 = . | title = Hepatic epithelioid hemangioendothelioma: A diagnostic pitfall in aspiration cytology. | journal = Cytojournal | volume = 6 | issue = | pages = 25 | month = | year = 2010 | doi = 10.4103/1742-6413.58951 | PMID = 20165548 | URL = http://www.biomedsearch.com/nih/Hepatic-epithelioid-hemangioendothelioma-diagnostic-pitfall/20165548.html }}</ref> | |||
*Large epithelioid perivascular cells with: | |||
**Abundant pale eosinophilic cytoplasm. | |||
**Cytoplasmic vacuolation (some cells) - [[AKA]] "blister cells" - '''key feature'''. | |||
***May form lumen and have RBC within. | |||
**Vesicular nucleus with prominent nucleolus in some cells. | |||
*Tuft-like projections into capillaries. | |||
*Tumour cells may be in well-circumscribed paucicellular nodules ''or'' more cellular poorly formed aggregates. | |||
DDx: | |||
*[[Angiosarcoma]], epithelioid. | |||
*[[Hemangioma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Epithelioid_hemangioendothelioma.jpg | Epithelioid hemangioendothelioma. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.flickr.com/photos/pulmonary_pathology/5600772691/in/photostream/ Epithelioid hemangioendothelioma - low mag. (flickr.com/Rosen)]. | |||
*[http://www.flickr.com/photos/pulmonary_pathology/5601354962/ Epithelioid hemangioendothelioma - high mag. (flickr.com/Rosen)]. | |||
*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170854495 Epithelioid hemangioendothelioma (surgicalpathologyatlas.com)]. | |||
==IHC== | |||
Features:<ref name=pmid20165548>{{Cite journal | last1 = Gupta | first1 = R. | last2 = Mathur | first2 = SR. | last3 = Gupta | first3 = SD. | last4 = Durgapal | first4 = P. | last5 = Iyer | first5 = VK. | last6 = Das | first6 = CJ. | last7 = Shalimar | first7 = SK. | last8 = Acharya | first8 = . | title = Hepatic epithelioid hemangioendothelioma: A diagnostic pitfall in aspiration cytology. | journal = Cytojournal | volume = 6 | issue = | pages = 25 | month = | year = 2010 | doi = 10.4103/1742-6413.58951 | PMID = 20165548 | URL = http://www.biomedsearch.com/nih/Hepatic-epithelioid-hemangioendothelioma-diagnostic-pitfall/20165548.html }}</ref> | |||
*CD31 +ve. | |||
*CD34 +ve. | |||
*Factor VIII +ve. | |||
==See also== | |||
*[[Vascular tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Vascular tumours]] | |||