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Difference between revisions of "Basal crypt dysplasia"
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'''Basal crypt dysplasia''', abbreviated '''BCD''' or '''CD''', is a dysplastic change that involves the crypt bases but ''not'' the surface.<ref>{{Cite journal | last1 = Khan | first1 = S. | last2 = McDonald | first2 = SA. | last3 = Wright | first3 = NA. | last4 = Graham | first4 = TA. | last5 = Odze | first5 = RD. | last6 = Rodriguez-Justo | first6 = M. | last7 = Zeki | first7 = S. | title = Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells. | journal = J Pathol | volume = 231 | issue = 1 | pages = 98-104 | month = Sep | year = 2013 | doi = 10.1002/path.4211 | PMID = 23695891 }}</ref> | '''Basal crypt dysplasia''', abbreviated '''BCD''' or '''CD''', is a dysplastic change that involves the crypt bases but ''not'' the surface.<ref name=pmid23695891>{{Cite journal | last1 = Khan | first1 = S. | last2 = McDonald | first2 = SA. | last3 = Wright | first3 = NA. | last4 = Graham | first4 = TA. | last5 = Odze | first5 = RD. | last6 = Rodriguez-Justo | first6 = M. | last7 = Zeki | first7 = S. | title = Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells. | journal = J Pathol | volume = 231 | issue = 1 | pages = 98-104 | month = Sep | year = 2013 | doi = 10.1002/path.4211 | PMID = 23695891 }}</ref> | ||
It may be referred to as '''crypt dysplasia'''. | |||
==General== | |||
*Molecular changes in the crypt base can be identified in the surface cells.<ref name=pmid23695891/> | |||
==Microscopic== | ==Microscopic== | ||
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**Nuclear enlargement. | **Nuclear enlargement. | ||
**Nuclear crowding (pseudostratification). | **Nuclear crowding (pseudostratification). | ||
*Non-dysplastic (normal) surface epithelium. | *Non-dysplastic (normal) surface epithelium.<ref name=pmid23695891/> | ||
==See also== | ==See also== | ||
*[[Malignancy]]. | *[[Malignancy]]. | ||
*[[Esophagus]]. | *[[Esophagus]]. | ||
*[[Barrett's esophagus]]. | |||
==References== | ==References== | ||