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'''Chondroblastoma''' is a benign [[chondro-osseous tumour]] that afflicts the young (growth plates open). | |||
==General== | |||
*Growth plate lesion. | |||
*Sclerotic margin. | |||
*"Young" = growth plates open. | |||
*Typically painful.<ref name=Ref_PCPBoD8_625>{{Ref PCPBoD8|625}}</ref> | |||
==Gross== | |||
*Well-defined lesion. | |||
===Image=== | |||
*[http://www.flickr.com/photos/35441329@N05/4052875138/in/set-72157622681280610 Chondroblastoma (flickr.com/humpath)]. | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP_642>{{Ref WMSP|642}}</ref> | |||
*Abundant extracellular material - pink on [[H&E stain]] - looks vaguely like cartilage. | |||
*Chondroblasts: | |||
**Nuclear morphology variable: ovoid, folded or grooved. | |||
**Moderate-abundant eosinophilic cytoplasm. | |||
*+/-Calcification surrounds the cell nests ("chickenwire" appearance) - '''classic feature'''. | |||
**Cell nests have a thin pale blue rimming. | |||
*+/-[[Giant cells]]. | |||
**May lead to confusion with ''[[giant cell tumour of bone]]''. | |||
DDx: | |||
*[[Giant cell tumour of bone]]. | |||
*[[Chondroma]]. | |||
*Well-differentiated [[chondrosarcoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Chondroblastoma_-_intermed_mag.jpg | Chondroblastoma - intermed. mag. (WC) | |||
Image:Chondroblastoma_-_very_high_mag.jpg | Chondroblastoma - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-996.jpg Chondroblastoma (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref> | |||
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-997.jpg Chondroblastoma with "chickenwire" appearance (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref> | |||
*[http://path.upmc.edu/cases/case494/images/fig2a.jpg Chondroblastoma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case494.html http://path.upmc.edu/cases/case494.html]. Accessed on: 24 January 2012.</ref> | |||
==IHC== | |||
Features:<ref name=Ref_WMSP_642>{{Ref WMSP|642}}</ref> | |||
*S100 +ve. | |||
*Vimentin +ve.<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref> | |||
==See also== | |||
*[[Chondro-osseous tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Chondro-osseous tumours]] | |||