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Atypical polypoid adenomyoma of the uterus (view source)
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'''Atypical polypoid adenomyoma of the uterus''' is a rare benign lesion of the [[uterus]]. | |||
It is usually referred to simply as '''atypical polypoid adenomyoma''' (abbreviated '''APA'''). | |||
==General== | |||
*Very rare.<ref name=pmid21684185>{{Cite journal | last1 = Terada | first1 = T. | title = Atypical polypoid adenomyoma of the uterus: an immunohistochemical study on 5 cases. | journal = Ann Diagn Pathol | volume = 15 | issue = 5 | pages = 338-41 | month = Oct | year = 2011 | doi = 10.1016/j.anndiagpath.2011.03.008 | PMID = 21684185 }}</ref> | |||
*Benign.<ref name=pmid17050990/> | |||
*Reproductive age women. | |||
==Gross== | |||
*Lower uterine segment. | |||
==Microscopic== | |||
Features:<ref name=pmid17050990>{{Cite journal | last1 = Jakus | first1 = S. | last2 = Edmonds | first2 = P. | last3 = Dunton | first3 = C. | last4 = Holland | first4 = G. | title = Atypical polypoid adenomyoma mimicking cervical adenocarcinoma. | journal = J Low Genit Tract Dis | volume = 6 | issue = 1 | pages = 33-8 | month = Jan | year = 2002 | doi = | PMID = 17050990 }}</ref> | |||
*Glands with irregular (non-ovoid) shapes. | |||
*Benign smooth muscle around the glands - '''key feature'''. | |||
*Morular squamous metaplasia - balls of squamous cells - very common. | |||
*Nuclear atypia (mild). | |||
DDx: | |||
*[[Endometrioid endometrial carcinoma]]. | |||
*[[Endometrium with squamous morules]] - more common. | |||
*Endocervical adenocarcinoma. | |||
===Images=== | |||
<gallery> | |||
Image:Atypical_polypoid_adenomyoma_-_intermed_mag.jpg | APA - intermed. mag. (WC) | |||
Image:Atypical_polypoid_adenomyoma_-_high_mag.jpg | APA - high mag. (WC) | |||
Image:Atypical_polypoid_adenomyoma_-_very_high_mag.jpg | APA - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.pathologypics.com/PictView.aspx?ID=1220 APA (pathologypics.com)]. | |||
==IHC== | |||
Features (glandular component):<ref name=pmid21684185/> | |||
*AE1/AE3 +ve. | |||
*CK7 +ve. | |||
*ER +ve. | |||
*PR +ve. | |||
Significant negative (glandular component):<ref name=pmid21684185/> | |||
*[[CK20]] -ve. | |||
*CEA -ve. | |||
==Sign out== | |||
<pre> | |||
ENDOMETRIUM, CURETTAGE: | |||
- ATYPICAL POLYPOID ADENOMYOMA. | |||
COMMENT: | |||
Atypical polypoid adenomyomas are considered to be benign lesions; however, | |||
they may persist or recur in up to half of patients. | |||
</pre> | |||
==See also== | |||
*[[Uterine tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Uterine tumours]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||