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Difference between revisions of "Urothelial carcinoma in situ"
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Urothelial carcinoma in situ (view source)
Revision as of 00:21, 19 March 2014
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Urothelial carcinoma in situ -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Urothelial carcinoma in situ. [[H&E stain]]. | ||
| Synonyms = high-grade dysplasia | | Synonyms = high-grade dysplasia | ||
| Micro = | | Micro = nuclear changes (enlargement of nuclei (often 4-5x the size of stromal lymphocytes), nuclear pleomorphism - marked variation in size of nuclei), +/-disordered arrangement/crowding of cells, +/-mitoses, +/-enlarged nucleoli | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[urothelial carcinoma]], [[urothelial dysplasia]] | | LMDDx = [[urothelial carcinoma]], [[urothelial dysplasia]], urothelial atypia of unknown significance | ||
| Stains = | | Stains = | ||
| IHC = CK20 +ve (full thickness), Ki-67 high, p53 +ve, CD44 -ve, CK7 +ve | | IHC = CK20 +ve (full thickness), Ki-67 high, p53 +ve, CD44 -ve, CK7 +ve | ||