Difference between revisions of "Lymphoma"

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Lymphoma (view source)

Revision as of 03:48, 9 March 2014

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→‎Primary mediastinal B-cell lymphoma: split out
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*Abbreviated ''PMBL''.
*Abbreviated ''PMBL''.
*[[AKA]] ''primary mediastinal large B-cell lymphoma''.
*[[AKA]] ''primary mediastinal large B-cell lymphoma''.
 
{{Main|Primary mediastinal B-cell lymphoma}}
===General===
Features:<ref name=pmid19074109 >{{Cite journal  | last1 = Johnson | first1 = PW. | last2 = Davies | first2 = AJ. | title = Primary mediastinal B-cell lymphoma. | journal = Hematology Am Soc Hematol Educ Program | volume =  | issue =  | pages = 349-58 | month =  | year = 2008 | doi = 10.1182/asheducation-2008.1.349 | PMID = 19074109 }}</ref><ref name=pmid20207294>{{Cite journal  | last1 = Coso | first1 = D. | last2 = Rey | first2 = J. | last3 = Bouabdallah | first3 = R. | title = [Primary mediastinal B-cell lymphoma] | journal = Rev Pneumol Clin | volume = 66 | issue = 1 | pages = 32-5 | month = Feb | year = 2010 | doi = 10.1016/j.pneumo.2009.12.007 | PMID = 20207294 }}</ref>
*Rare.
*Young adults.
*[[Mediastinum]].
 
===Microscopic===
Features:
*Atypical large lymphoid cells - see ''[[DLBCL]]''.
*Classically associated with:
**Fibrosis
**Clear cells.
 
Note:
*Neither fibrosis or clear cells are required for the [[diagnosis]] nor are they pathognomonic.<ref name=pmid11251018 >{{Cite journal  | last1 = van Besien | first1 = K. | last2 = Kelta | first2 = M. | last3 = Bahaguna | first3 = P. | title = Primary mediastinal B-cell lymphoma: a review of pathology and management. | journal = J Clin Oncol | volume = 19 | issue = 6 | pages = 1855-64 | month = Mar | year = 2001 | doi =  | PMID = 11251018 }}</ref>
 
DDx:
*Other types of [[DLBCL]].
*Poorly differentiated carcinoma.
 
Images:
*[[WC]]:
**[http://commons.wikimedia.org/wiki/File:Primary_mediastinal_large_B-cell_lymphoma_-_very_high_mag.jpg PMBL - very high mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Primary_mediastinal_large_B-cell_lymphoma_-_intermed_mag.jpg PMBL - intermed. mag. (WC)].
*www:
**[http://path.upmc.edu/cases/case371.html PMBL - several images (upmc.edu)].
 
===Sign out===
<pre>
MASS, ANTERIOR MEDIASTINAL, CORE BIOPSY:
- LARGE B-CELL LYMPHOMA IN A FIBROTIC BACKGROUND WITH NECROSIS, SEE COMMENT
 
COMMENT:
Morphology:
Tumour cells: size ~2x a mature lymphocyte, a moderate quantity of grey/basophilic
  cytoplasm, no clear cells are identified.
Cells intermixed with tumour: mature lymphocytes, rare eosinophils.
Architecture: no gland formation, discohesive, no follicles apparent, extensive fibrosis.
 
Tumour cells:
POSITIVE: CD45, CD20, CD10, BCL-6, BCL-2.
NEGATIVE: pankeratin, PLAP, CD3, CD30.
Ki-67: 50% of large (lymphoid) cells.
</pre>


==Anaplastic large cell lymphoma==
==Anaplastic large cell lymphoma==
Michael
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