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Difference between revisions of "Enteropathy-associated T-cell lymphoma"
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Enteropathy-associated T-cell lymphoma (view source)
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'''Enteropathy-associated T-cell lymphoma''', abbreviated ''EATL'', is an uncommon type of [[lymphoma]] associated with [[celiac disease]]. | |||
It is also known as '''enteropathy-type T-cell lymphoma''', abbreviated '''ETTL'''. | |||
==General== | |||
*T cell lymphoma due to [[celiac sprue]]. | |||
*Subdivided into type I and type II.<ref name=pmid21566094>{{cite journal |author=Delabie J, et al |title=Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project|journal=Blood |volume=118|issue=148|pages= 148|year=2011|month=July}}</ref> | |||
==Microscopic== | |||
Features:<ref name=pmid21323966>{{Cite journal | last1 = Takeshita | first1 = M. | last2 = Nakamura | first2 = S. | last3 = Kikuma | first3 = K. | last4 = Nakayama | first4 = Y. | last5 = Nimura | first5 = S. | last6 = Yao | first6 = T. | last7 = Urabe | first7 = S. | last8 = Ogawara | first8 = S. | last9 = Yonemasu | first9 = H. | title = Pathological and immunohistological findings and genetic aberrations of intestinal enteropathy-associated T cell lymphoma in Japan. | journal = Histopathology | volume = 58 | issue = 3 | pages = 395-407 | month = Feb | year = 2011 | doi = 10.1111/j.1365-2559.2011.03768.x | PMID = 21323966 }}</ref> | |||
*Large ''or'' medium-sized lymphoid cells in the mucosa and submucosa. | |||
**Large-sized cells ~ 2x RBC diameter = type 1. | |||
**Medium sized cells ~ 1.5x RBC diameter = type 2. | |||
*Intestinal epithelium usually preserved. | |||
===Image=== | |||
<gallery> | |||
Image:Enteropathy-associated_T_cell_lymphoma_-_low_mag.jpg | EATL. (WC) | |||
</gallery> | |||
==IHC== | |||
Features - type 1:<ref name=pmid21323966/> | |||
*CD56 +ve. | |||
Features - type 2:<ref name=pmid21323966/><ref name=pmid21921780>{{Cite journal | last1 = Chan | first1 = JK. | last2 = Chan | first2 = AC. | last3 = Cheuk | first3 = W. | last4 = Wan | first4 = SK. | last5 = Lee | first5 = WK. | last6 = Lui | first6 = YH. | last7 = Chan | first7 = WK. | title = Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent γδ T-cell receptor expression. | journal = Am J Surg Pathol | volume = 35 | issue = 10 | pages = 1557-69 | month = Oct | year = 2011 | doi = 10.1097/PAS.0b013e318222dfcd | PMID = 21921780 }}</ref> | |||
*CD3 +ve. | |||
*CD5 -ve. | |||
*CD8 -ve/+ve. | |||
*CD56 -ve/+ve. | |||
*CD30 +ve. | |||
==See also== | |||
*[[Lymphoma]]. | |||
*[[Celiac disease]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Lymphoma]] | |||