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Difference between revisions of "Desmoid-type fibromatosis"
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→IHC
(→Microscopic: sm fix.) |
(→IHC) |
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Features:<ref name=Ref_WMSP609>{{Ref WMSP|609}}</ref> | Features:<ref name=Ref_WMSP609>{{Ref WMSP|609}}</ref> | ||
*Beta-catenin +ve (nuclear<ref name=pmid23020601/>) - '''important'''. | *Beta-catenin +ve (nuclear<ref name=pmid23020601/>) - '''important'''. | ||
**100% sensitive... may not be completely specific (?).<ref name=pmid17721184>{{Cite journal | last1 = Amary | first1 = MF. | last2 = Pauwels | first2 = P. | last3 = Meulemans | first3 = E. | last4 = Roemen | first4 = GM. | last5 = Islam | first5 = L. | last6 = Idowu | first6 = B. | last7 = Bousdras | first7 = K. | last8 = Diss | first8 = TC. | last9 = O'Donnell | first9 = P. | title = Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool. | journal = Am J Surg Pathol | volume = 31 | issue = 9 | pages = 1299-309 | month = Sep | year = 2007 | doi = 10.1097/PAS.0b013e31802f581a | PMID = 17721184 }}</ref> | |||
*SMA +ve ~50% of lesions. | *SMA +ve ~50% of lesions. | ||