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Difference between revisions of "Non-invasive breast carcinoma"
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Non-invasive breast carcinoma (view source)
Revision as of 23:58, 28 November 2010
, 23:58, 28 November 2010+ADH, more on lobular hyperplasia, re-organize
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Invasive breast cancer is dealt with in the article ''[[invasive breast cancer]]''. | Invasive breast cancer is dealt with in the article ''[[invasive breast cancer]]''. | ||
=Ductal neoplasia= | |||
This category includes: | |||
#Atypical ductal hyperplasia (ADH). | |||
#Ductal carcinoma in situ (DCIS). | |||
*These entities (ADH, DCIS) have some over lap. | |||
*The difference ''is'': | |||
*#The degree of nuclear atypia; high grade is DCIS. | |||
*#The extent; small lesions are ADH, large lesions (low-grade) DCIS. | |||
==Ductal carcinoma in situ== | ==Ductal carcinoma in situ== | ||
| Line 119: | Line 129: | ||
*DCIS - excision (lumpectomy) + radiation. | *DCIS - excision (lumpectomy) + radiation. | ||
*Invasive ductal carcinoma - excision with sentinel lymph node disection<ref>Sentinel Lymph Node Biopsy: What Breast Cancer Patients Need to Know. cancernews.com. URL: [http://www.cancernews.com/data/Article/202.asp http://www.cancernews.com/data/Article/202.asp]. Accessed on: 9 October 2009.</ref> and radiation. | *Invasive ductal carcinoma - excision with sentinel lymph node disection<ref>Sentinel Lymph Node Biopsy: What Breast Cancer Patients Need to Know. cancernews.com. URL: [http://www.cancernews.com/data/Article/202.asp http://www.cancernews.com/data/Article/202.asp]. Accessed on: 9 October 2009.</ref> and radiation. | ||
=Lobular neoplasia= | |||
==Overview== | |||
Includes: | |||
#Atypical lobular hyperplasia (ALH). | |||
#Lobular carcinoma in situ (LCIS). | |||
*These entities (ALH, LCIS) are near identical from a histomorphologic perspective. | |||
*The difference is extent of involvement: | |||
**ALH <50% of terminal duct lobular unit (TDLU) is involved. | |||
**LCIS >=50% of TDLU is involved. | |||
==Atypical lobular hyperplasia== | |||
*Abbreviated ''ALH''. | |||
===Microscopic=== | |||
See ''LCIS''. | |||
==Lobular carcinoma in situ== | ==Lobular carcinoma in situ== | ||
*Abbreviated ''LCIS''. | *Abbreviated ''LCIS''. | ||
===General=== | |||
*Management is currently some matter of debate. | *Management is currently some matter of debate. | ||
*Not detected radiologically - it is an incidental pathologic finding. | *Not detected radiologically - it is an incidental pathologic finding. | ||
==See also | ===Microscopic=== | ||
Features:<ref name=Ref_TPoSP188>{{Ref TPoSP|188}}</ref><ref name=Ref_BP170>{{Ref BP|170}}</ref> | |||
*Cells distend the duct. | |||
*Dyscohesive - distinct cell border visible. | |||
*Clear cytoplasm (focally); may have signet ring cell-like appearance. | |||
*Eccentrically placed round nucleus, | |||
**Usually minimal atypia, relatively small ~1-2x size lymphocyte. | |||
**+/-Nucleolus. | |||
====Subclassification<ref name=Ref_BP170>{{Ref BP|170}}</ref>==== | |||
*Non-PLCIS. | |||
**Type A. | |||
***Nucleus 1-1.5x lymphocyte. | |||
***No nucleolus. | |||
**Type B. | |||
***Nucleus ~2x lymphocyte. | |||
***Nucleolus present. | |||
*PLCIS (pleomorphic lobular carcinoma in situ). | |||
Main DDx: | |||
*Low-grade DCIS. | |||
=See also= | |||
*[[Breast]]. | *[[Breast]]. | ||
*[[Invasive breast cancer]]. | *[[Invasive breast cancer]]. | ||
=References= | |||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Breast pathology]] | [[Category:Breast pathology]] | ||