Difference between revisions of "Neuromuscular pathology"

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Neuromuscular pathology (view source)

Revision as of 18:02, 28 November 2010

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**Men: 24-195 unit/litre.
**Men: 24-195 unit/litre.
**Women: 24-170 units/litre.
**Women: 24-170 units/litre.
==Patterns==
===Overview===
{{familytree/start}}
{{familytree | | | | | | | | | A01 | | | | | |A01=Neuromuscular<br>pathology}}
{{familytree | | | | |,|-|-|-|-|+|-|-|-|-|.| |}}
{{familytree | | | | B01 | | | B02 | | | B03|B01=Neurogenic|B02=Myogenic|B03=Other/Mixed }}
{{familytree/end}}
{| class="wikitable"
|
| '''Neurogenic'''
| '''Myogenic'''
| Notes
| Image
|-
| Shape of fibres
| angulated
| round
|
| [http://nmdinfo.org/lectures/wineinger/wineinger/ppt/Slide25.JPG round fibres]<ref>URL: [http://nmdinfo.org/lectures/info.php?id=8 http://nmdinfo.org/lectures/info.php?id=8]. Accessed on: 25 October 2010.</ref>
|-
| Small fibres
| groups <br>("group atrophy")
| singular
|
| [http://neuropathology.neoucom.edu/chapter9/images9/13-7.jpg group atrophy]<ref>URL: [http://neuropathology.neoucom.edu/chapter9/chapter9fALS.html http://neuropathology.neoucom.edu/chapter9/chapter9fALS.html]. Accessed on: 25 October 2010.</ref>
|-
| Large fibres<br>
| no
| +/-scattered
| "hypercontracted<br>fibres"
| [http://commons.wikimedia.org/wiki/File:Duchenne-muscular-dystrophy.jpg DMD (WC)]
|-
| Fibre type<br>grouping
| yes (d/t chronic <br>denervation + <br>reinnervation)<ref>URL: [http://neuromuscular.wustl.edu/lab/mbiopsy.htm#fibertype http://neuromuscular.wustl.edu/lab/mbiopsy.htm#fibertype]. Accessed on: 26 October 2010.</ref>
| yes (???)
| based on ATPase, <br>NADH-TR stains
| [http://missinglink.ucsf.edu/lm/ids_104_musclenerve_path/student_musclenerve/subpages/ng.atp.9.4.1.html ATPase 9.4]<ref>URL: [http://missinglink.ucsf.edu/lm/ids_104_musclenerve_path/student_musclenerve/musclepath.html http://missinglink.ucsf.edu/lm/ids_104_musclenerve_path/student_musclenerve/musclepath.html]. Accessed on: 26 October 2010.</ref>, [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com04Image/Com401-3-12.gif NADH-TR]<ref>URL: [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm]. Accessed on: 28 October 2010.</ref>
|}
====List====
Neurogenic:
*Angulated myocytes.
*Groups of small fibres.
*Apparent increase of nuclei.
Myogenic:
*Round myocytes.
*+/-Intense (darker) cytoplasm.
*+/-Fibrosis (between fibres).
*+/-Necrosis.
===Detail===
#Segmental demyelination - nerve/CNS abnormality.
#Axonal degeneration - nerve/CNS abnormality.
#Reinnervation - nerve injury.
#Myopathy - something is wrong with the muscle fibres.


==Muscle structure/histology==
==Muscle structure/histology==
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===Normal findings===
===Normal findings===
*Muscle-tendon junction - myofibrils frayed + adjacent to dense connective tissue.
====Muscle-tendon junction====
Features:
*Myofibrils frayed + adjacent to dense connective tissue.
**Image: [http://www.lab.anhb.uwa.edu.au/mb140/corepages/connective/Images/mtj040vg.jpg Muscle-tendon junction (anhb.uwa.edu.au)].<ref>URL: [http://www.lab.anhb.uwa.edu.au/mb140/corepages/connective/connect.htm http://www.lab.anhb.uwa.edu.au/mb140/corepages/connective/connect.htm]. Accessed on: 4 November 2010.</ref>
**Image: [http://www.lab.anhb.uwa.edu.au/mb140/corepages/connective/Images/mtj040vg.jpg Muscle-tendon junction (anhb.uwa.edu.au)].<ref>URL: [http://www.lab.anhb.uwa.edu.au/mb140/corepages/connective/connect.htm http://www.lab.anhb.uwa.edu.au/mb140/corepages/connective/connect.htm]. Accessed on: 4 November 2010.</ref>
====Muscle-nerve junction====
Features:
*Dunno. (???)
Images:
*[http://commons.wikimedia.org/wiki/File:Skeletal_muscle_-_cross_section,_nerve_bundle.jpg MN junction - crappy image (WC)]. (???)
====Muscle spindle====
Features:
*Weird looking muscle cell. (???)
Image: [http://www.lab.anhb.uwa.edu.au/mb140/corepages/muscle/Images/mspindle041he.jpg Muscle spindle (anhb.uwa.edu.au)].<ref>URL: [http://www.lab.anhb.uwa.edu.au/mb140/corepages/muscle/muscle.htm http://www.lab.anhb.uwa.edu.au/mb140/corepages/muscle/muscle.htm]. Accessed on: 28 November 2010.</ref>


===Abnormal findings===
===Abnormal findings===
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**Stained with methylene blue.<ref>URL: [http://www.nature.com/modpathol/journal/v18/n5/full/3800344a.html http://www.nature.com/modpathol/journal/v18/n5/full/3800344a.html]. Accessed on: 26 November 2010.</ref> (???)
**Stained with methylene blue.<ref>URL: [http://www.nature.com/modpathol/journal/v18/n5/full/3800344a.html http://www.nature.com/modpathol/journal/v18/n5/full/3800344a.html]. Accessed on: 26 November 2010.</ref> (???)
*Normal SMH numbering = "paraffin".
*Normal SMH numbering = "paraffin".
==Patterns (pathologic)==
===Overview===
{{familytree/start}}
{{familytree | | | | | | | | | A01 | | | | | |A01=Neuromuscular<br>pathology}}
{{familytree | | | | |,|-|-|-|-|+|-|-|-|-|.| |}}
{{familytree | | | | B01 | | | B02 | | | B03|B01=Neurogenic|B02=Myogenic|B03=Other/Mixed }}
{{familytree/end}}
{| class="wikitable"
|
| '''Neurogenic'''
| '''Myogenic'''
| Notes
| Image
|-
| Shape of fibres
| angulated
| round
|
| [http://nmdinfo.org/lectures/wineinger/wineinger/ppt/Slide25.JPG round fibres]<ref>URL: [http://nmdinfo.org/lectures/info.php?id=8 http://nmdinfo.org/lectures/info.php?id=8]. Accessed on: 25 October 2010.</ref>
|-
| Small fibres
| groups <br>("group atrophy")
| singular
|
| [http://neuropathology.neoucom.edu/chapter9/images9/13-7.jpg group atrophy]<ref>URL: [http://neuropathology.neoucom.edu/chapter9/chapter9fALS.html http://neuropathology.neoucom.edu/chapter9/chapter9fALS.html]. Accessed on: 25 October 2010.</ref>
|-
| Large fibres<br>
| no
| +/-scattered
| "hypercontracted<br>fibres"
| [http://commons.wikimedia.org/wiki/File:Duchenne-muscular-dystrophy.jpg DMD (WC)]
|-
| Fibre type<br>grouping
| yes (d/t chronic <br>denervation + <br>reinnervation)<ref>URL: [http://neuromuscular.wustl.edu/lab/mbiopsy.htm#fibertype http://neuromuscular.wustl.edu/lab/mbiopsy.htm#fibertype]. Accessed on: 26 October 2010.</ref>
| yes (???)
| based on ATPase, <br>NADH-TR stains
| [http://missinglink.ucsf.edu/lm/ids_104_musclenerve_path/student_musclenerve/subpages/ng.atp.9.4.1.html ATPase 9.4]<ref>URL: [http://missinglink.ucsf.edu/lm/ids_104_musclenerve_path/student_musclenerve/musclepath.html http://missinglink.ucsf.edu/lm/ids_104_musclenerve_path/student_musclenerve/musclepath.html]. Accessed on: 26 October 2010.</ref>, [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com04Image/Com401-3-12.gif NADH-TR]<ref>URL: [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm]. Accessed on: 28 October 2010.</ref>
|}
====List====
Neurogenic:
*Angulated myocytes.
*Groups of small fibres.
*Apparent increase of nuclei.
Myogenic:
*Round myocytes.
*+/-Intense (darker) cytoplasm.
*+/-Fibrosis (between fibres).
*+/-Necrosis.
===Detail===
#Segmental demyelination - nerve/CNS abnormality.
#Axonal degeneration - nerve/CNS abnormality.
#Reinnervation - nerve injury.
#Myopathy - something is wrong with the muscle fibres.


==Stains for muscle biopsies==
==Stains for muscle biopsies==
Michael
48,830

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