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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Differentiated_vulvar_intraepithelial_neoplasia_-_intermed_mag.jpg | |||
| Width = | |||
| Caption = Differentiated vulvar intraepithelial neoplasia. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = thickening of the stratum spinosum ([[acanthosis]]), elongation of rete ridges with bridging/anastomoses between rete ridges, nuclear atypia - esp. basal layer, nuclei in stratum corneum (parakeratosis), +/-atypical mitoses | |||
| Subtypes = | |||
| LMDDx = [[vulvar squamous cell carcinoma]], [[lichen sclerosus]], [[classical vulvar intraepithelial neoplasia]] | |||
| Stains = | |||
| IHC = p53 +ve, p16 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[vulva]] | |||
| Assdx = [[lichen sclerosus]], [[vulvar squamous cell carcinoma]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Differentiated vulvar intraepithelial neoplasia''', abbreviated '''dVIN''', is a pre-neoplastic pathology of the [[vulva]] typically arising in the context of [[lichen sclerosus]]. | '''Differentiated vulvar intraepithelial neoplasia''', abbreviated '''dVIN''', is a pre-neoplastic pathology of the [[vulva]] typically arising in the context of [[lichen sclerosus]]. | ||
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*[[Lichen sclerosus]]. | *[[Lichen sclerosus]]. | ||
*[[Lichen simplex chronicus]] (squamous hyperplasia). | *[[Lichen simplex chronicus]] (squamous hyperplasia). | ||
*[[Vulvar squamous cell carcinoma]]. | |||
===Images=== | ===Images=== |
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