Difference between revisions of "Lung tumours"

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Lung tumours (view source)

Revision as of 03:34, 18 February 2014

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→‎Solitary fibrous tumour of the pleura: split out
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==Solitary fibrous tumour of the pleura==
==Solitary fibrous tumour of the pleura==
:See also: ''[[Solitary fibrous tumour]]''.
{{Main|Solitary fibrous tumour of the pleura}}
===General===
*Uncommon overall.<ref name=pmid24326857/>
**Common for the anatomical site.
*Benign.
*Slow growing.<ref name=pmid24326857>{{Cite journal  | last1 = Mordenti | first1 = P. | last2 = Di Cicilia | first2 = R. | last3 = Delfanti | first3 = R. | last4 = Capelli | first4 = P. | last5 = Paties | first5 = C. | last6 = Cavanna | first6 = L. | title = Solitary fibrous tumors of the pleura: a case report and review of the literature. | journal = Tumori | volume = 99 | issue = 4 | pages = e177-83 | month =  | year =  | doi = 10.1700/1361.15120 | PMID = 24326857 }}</ref>
*Elderly.
*May be large - impair respiratory function.<ref name=pmid24088920>{{Cite journal  | last1 = Abe | first1 = M. | last2 = Nomori | first2 = H. | last3 = Fukazawa | first3 = M. | last4 = Sugimura | first4 = H. | last5 = Narita | first5 = M. | last6 = Takeshi | first6 = A. | title = Giant Solitary Fibrous Tumor of the Pleura Causing Respiratory Insufficiency: Report of 3 Cases. | journal = Ann Thorac Cardiovasc Surg | volume =  | issue =  | pages =  | month = Oct | year = 2013 | doi =  | PMID = 24088920 }}</ref>
 
===Gross/radiology===
*Chest wall.
 
===Microscopic===
Features:
*Spindle cells - usually bland cytology.
*Patternless pattern.
*+/-Ropy collagen.
 
Suggestive of malignant:<ref name=pmid24088920/>
*Mitotic rate >4/10 HPF.
**Definition suffers from [[HPFitis]].
 
DDx:
*[[Malignant mesothelioma]].
*Metastatic carcinoma.
*[[Lung adenocarcinoma]].
 
====Images====
<gallery>
Image:Pleural solitary fibrous tumor (1).jpg | Pleural SFT. (WC)
Image:Pleural solitary fibrous tumor (2).jpg | Pleural SFT. (WC)
Image:Pleural solitary fibrous tumor (3).jpg | Pleural SFT. (WC)
</gallery>
www:
*[http://path.upmc.edu/cases/case216/dx.html SFT (upmc.edu)].
 
===IHC===
Features:
*CD34 +ve (19/23 cases<ref name=pmid15460417>{{Cite journal  | last1 = Chen | first1 = HJ. | last2 = Zhang | first2 = HY. | last3 = Li | first3 = X. | last4 = Guo | first4 = LX. | last5 = Wei | first5 = B. | last6 = Guo | first6 = H. | last7 = Bu | first7 = H. | last8 = Yang | first8 = K. | last9 = Liu | first9 = BL. | title = [Solitary fibrous tumor: the clinicopathologic and immunohistochemical characteristics of 26 cases]. | journal = Sichuan Da Xue Xue Bao Yi Xue Ban | volume = 35 | issue = 5 | pages = 675-9 | month = Sep | year = 2004 | doi =  | PMID = 15460417 }}</ref>).
*Ki-67 low (<5%).<ref name=pmid24088920/>
*Vimentin +ve (23/23 cases<ref name=pmid15460417/>).
*BCL2 +ve (23/23 cases<ref name=pmid15460417/>).
*CD99 +ve (23/23 cases<ref name=pmid15460417/>).
*SMA -ve/+ve (7 +ve/23 cases<ref name=pmid15460417/>).
 
Suggested stains:{{fact}}
*CD34, CD99, BCL2, S-100, Ki-67.
 
===Sign out===
<pre>
LEFT LUNG ("LARGE PLEURAL BASED MASS"), BIOPSY:
- SOLITARY FIBROUS TUMOUR.
</pre>
====Micro====
The sections show cellular fibrous tissue with a patternless pattern. No mitotic activity is readily apparent. No significant nuclear atypia is identified. No necrosis is apparent.


=Benign tumours=
=Benign tumours=
Michael
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