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Aggressive angiomyxoma (view source)
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# | '''Aggressive angiomyxoma''', also '''deep aggressive angiomyxoma''', is a rare benign lesion, typically of the [[vulva]], with a locally aggressive behaviour. | ||
==General== | |||
*Classically a [[vulva]]r mass or (less commonly) a [[scrotum|scrotal]] mass. | |||
**Case report of a thigh lesion.<ref name=pmid18338163>{{Cite journal | last1 = Heffernan | first1 = EJ. | last2 = Hayes | first2 = MM. | last3 = Alkubaidan | first3 = FO. | last4 = Clarkson | first4 = PW. | last5 = Munk | first5 = PL. | title = Aggressive angiomyxoma of the thigh. | journal = Skeletal Radiol | volume = 37 | issue = 7 | pages = 673-8 | month = Jul | year = 2008 | doi = 10.1007/s00256-008-0465-0 | PMID = 18338163 }}</ref> | |||
*Benign - no metastatic potential. | |||
*"Aggressive" as it has a high recurrance. | |||
==Gross== | |||
*Poorly circumscribed. | |||
*"Rubbery" or "gelatinous". | |||
Location: | |||
*[[Vulva]] - classic location. | |||
Clinical DDx: | |||
*[[Bartholin cyst]]. | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP624>{{Ref WMSP|624}}</ref> | |||
#Thick blood vessels that meld into the surrounding stroma - '''key feature'''. | |||
#[[Myxoid stroma]] - '''key feature'''. | |||
#Small stellate cell/spindle cells without significant nuclear atypia. | |||
DDx: | |||
*[[Angiomyofibroblastoma]].<ref name=pmid1314521>{{Cite journal | last1 = Fletcher | first1 = CD. | last2 = Tsang | first2 = WY. | last3 = Fisher | first3 = C. | last4 = Lee | first4 = KC. | last5 = Chan | first5 = JK. | title = Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma. | journal = Am J Surg Pathol | volume = 16 | issue = 4 | pages = 373-82 | month = Apr | year = 1992 | doi = | PMID = 1314521 }}</ref> | |||
*[[Neurofibroma]]. | |||
*[[Myxoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Aggressive_angiomyxoma_-_intermed_mag.jpg | Aggressive angiomyxoma - intermed. mag. (WC/Nephron) | |||
Image:Aggressive_angiomyxoma_-_very_high_mag.jpg | Aggressive angiomyxoma - very high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=1&Case=99 Aggressive angiomyxoma - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?case=99&n=2 Aggressive angiomyxoma - high mag. (webpathology.com)]. | |||
*[http://path.upmc.edu/cases/case538.html Aggressive angiomyxoma - several images (upmc.edu)]. | |||
==IHC== | |||
Features:<ref name=Ref_WMSP624>{{Ref WMSP|624}}</ref> | |||
*Desmin +ve. | |||
*Vimentin +ve. | |||
*ER +ve. | |||
*PR +ve. | |||
==See also== | |||
[[Soft tissue lesions]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Soft tissue lesions]] | |||