Difference between revisions of "Spleen"

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Spleen (view source)

Revision as of 21:15, 16 February 2014

2,315 bytes removed ,  21:15, 16 February 2014
→‎Littoral cell angioma: split out
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:For ''angioma'' see ''[[vascular malformations]]''.
:For ''angioma'' see ''[[vascular malformations]]''.
*[[AKA]] ''littoral cell angioma of the spleen''.
*[[AKA]] ''littoral cell angioma of the spleen''.
===General===
{{Main|Littoral cell angioma}}
Features:<ref name=pmid15329769>{{Cite journal  | last1 = Tan | first1 = YM. | last2 = Chuah | first2 = KL. | last3 = Wong | first3 = WK. | title = Littoral cell angioma of the spleen. | journal = Ann Acad Med Singapore | volume = 33 | issue = 4 | pages = 524-6 | month = Jul | year = 2004 | doi =  | PMID = 15329769 | url=http://www.annals.edu.sg/pdf200408/V33N4p524.pdf }}</ref>
*Rare.
*Benign.
 
Clinical:<ref name=pmid15329769/><ref name=pmid11547761>{{Cite journal  | last1 = Dascalescu | first1 = CM. | last2 = Wendum | first2 = D. | last3 = Gorin | first3 = NC. | title = Littoral-cell angioma as a cause of splenomegaly. | journal = N Engl J Med | volume = 345 | issue = 10 | pages = 772-3 | month = Sep | year = 2001 | doi = 10.1056/NEJM200109063451016 | PMID = 11547761 | url=http://www.nejm.org/doi/full/10.1056/NEJM200109063451016 }}</ref>
*Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging.
 
Note:
*''Littoral cells'' = line vascular channels of the red pulp.<ref name=pmid15329769/>
**''Littoral'' = related to ''shore''.<ref>URL: [http://www.merriam-webster.com/dictionary/littoral http://www.merriam-webster.com/dictionary/littoral]. Accessed on: 24 July 2011.</ref><ref>URL: [http://dictionary.reference.com/browse/littoral http://dictionary.reference.com/browse/littoral]. Accessed on: 24 July 2011.</ref>
 
===Microscopic===
Features:<ref name=pmid15329769/>
*Anastoming, small vascular channels.
*Cystic spaces.
**May have papillary projections.<ref name=pmid11547761/>
 
DDx:<ref name=pmid15329769/>
*Vascular lesions:
**[[Hemangioendothelioma]].
**[[Angiosarcoma]].
**[[Hemangiopericytoma]].
**[[Splenic hamartoma]].
 
Images:
*[http://www.webpathology.com/image.asp?n=5&Case=382 LCA - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=6&Case=382 LCA - high mag. (webpathology.com)].
*[http://commons.wikimedia.org/wiki/File:Littoral_cell_angioma_of_the_spleen_-_very_low_mag.jpg LCA - very low mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Littoral_cell_angioma_of_the_spleen_-_intermed_mag.jpg LCA - intermed. mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Littoral_cell_angioma_of_the_spleen_-_very_high_mag.jpg LCA - very high mag. (WC)].
 
===IHC===
Features:<ref name=pmid15329769/>
*CD68 +ve.
*CD31 +ve
 
Others:
*CD34 -ve.
*Factor VIII +ve.


==Splenic hamartoma==
==Splenic hamartoma==
Michael
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