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Difference between revisions of "Medullary thyroid carcinoma"
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Medullary thyroid carcinoma (view source)
Revision as of 05:29, 16 February 2014
, 05:29, 16 February 2014no edit summary
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| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = | ||
| Stains = | | Stains = congo red +ve (amyloid deposits) | ||
| IHC = | | IHC = calcitonin +ve, CEA +ve, chromogranin A +ve, synaptophysin +ve, thyroglobulin -ve (usually) | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 90: | Line 90: | ||
Image:Medullary_thyroid_carcinoma_-_2_-_high_mag.jpg | MTC and amyloid - high mag. (WC) | Image:Medullary_thyroid_carcinoma_-_2_-_high_mag.jpg | MTC and amyloid - high mag. (WC) | ||
</gallery> | </gallery> | ||
==Stains== | |||
*Congo-red +ve (amyloid present) - mnemonic: ''CRAP'' -- congo red amyloid protein. | |||
==IHC== | ==IHC== | ||
Features:<ref>URL: [http://pathologyoutlines.com/thyroid.html#medullary http://pathologyoutlines.com/thyroid.html#medullary]. Accessed on: 17 January 2011.</ref> | Features:<ref>URL: [http://pathologyoutlines.com/thyroid.html#medullary http://pathologyoutlines.com/thyroid.html#medullary]. Accessed on: 17 January 2011.</ref> | ||
*[[Calcitonin]] +ve - it arises from C cells (which produce calcitonin). | *[[Calcitonin]] +ve - it arises from C cells (which produce calcitonin). | ||
*Neuroendocrine markers. | *Neuroendocrine markers. | ||
**[[Chromogranin A]]. | **[[Chromogranin A]]. | ||