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Mammary myofibroblastoma (view source)
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'''Mammary myofibroblastoma''' is a rare benign pathology of the [[breast]]. | |||
==General== | |||
*Rare. | |||
*Excision = cure. | |||
*Postmenopausal females and older males.<ref name=pmid18723968>{{Cite journal | last1 = Qureshi | first1 = A. | last2 = Kayani | first2 = N. | title = Myofibroblastoma of breast. | journal = Indian J Pathol Microbiol | volume = 51 | issue = 3 | pages = 395-6 | month = | year = | doi = | PMID = 18723968 }}</ref><ref name=pmid22096693>{{Cite journal | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month = | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 | PMC = 3199680 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/?tool=pubmed}}</ref> | |||
Note: | |||
*In extra-mammary sites the tumour is known as a ''mammary-type myofibroblastoma'' may immunohistochemically and histomorphologically overlap with [[spindle cell lipoma]].<ref name=pmid11474286>{{Cite journal | last1 = McMenamin | first1 = ME. | last2 = Fletcher | first2 = CD. | title = Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. | journal = Am J Surg Pathol | volume = 25 | issue = 8 | pages = 1022-9 | month = Aug | year = 2001 | doi = | PMID = 11474286 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_BP131>{{Ref BP|131}}</ref> | |||
*Well-circumscribed lesion. | |||
*Spindle cells without nuclear atypia arranged in fascicles. | |||
*Interspersed thick bundles of collagen. | |||
Notes: | |||
*No calcifications. | |||
*No necrosis. | |||
*No hemorrhage. | |||
DDx: | |||
*[[Metaplastic breast carcinoma]]. | |||
*Fibromatosis. | |||
*[[Leiomyoma]] of the breast. | |||
*[[Nodular fasciitis]]. | |||
*[[Phyllodes tumour]]. | |||
===Images=== | |||
<gallery> | |||
Image:Mammary_myofibroblastoma_-_low_mag.jpg | Mammary myofibroblastoma - low mag. (WC/Nephron) | |||
Image:Mammary_myofibroblastoma_-_intermed_mag.jpg | Mammary myofibroblastoma - intermed. mag. (WC/Nephron) | |||
Image:Mammary_myofibroblastoma_-_high_mag.jpg | Mammary myofibroblastoma - high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case249.html Mammary myofibroblastoma - several images (upmc.edu)]. | |||
==IHC== | |||
Features:<ref name=pmid22096693>{{Cite journal | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month = | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 }}</ref> | |||
*CD34 +ve.<ref name=pmid11474286/> | |||
*Desmin +ve.<ref name=pmid11474286/> | |||
*H-caldesmon +ve. | |||
*Actin +ve. | |||
*Vimentin +ve. | |||
Other | |||
*S100 -ve. | |||
*Beta-catenin -ve. (???) | |||
==See also== | |||
*[[Breast pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Breast pathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||