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Apocrine carcinoma of the breast (view source)
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'''Apocrine carcinoma of the breast''' is a rare form of [[invasive breast cancer]]. | |||
==General== | |||
*Need >=90% apocrine morphology.<ref name=Ref_BP217>{{Ref BP|217}}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_BP217>{{Ref BP|217}}</ref> | |||
*Prominent [[nucleoli]]. | |||
**Often multiple.<ref>{{Cite journal | last1 = O'Malley | first1 = FP. | last2 = Bane | first2 = A. | title = An update on apocrine lesions of the breast. | journal = Histopathology | volume = 52 | issue = 1 | pages = 3-10 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02888.x | PMID = 18171412 }}</ref> | |||
*Abundant granular eosinophilic cytoplasm. | |||
*Architecture like invasive ductal carcinomas ''no special type''. | |||
===Images=== | |||
www: | |||
*[http://path.upmc.edu/cases/case209/micro.html Apocrine carcinoma (upmc.edu)]. | |||
==IHC== | |||
Smaller tumours classically:<ref name=pmid16045781>{{Cite journal | last1 = Honma | first1 = N. | last2 = Takubo | first2 = K. | last3 = Akiyama | first3 = F. | last4 = Sawabe | first4 = M. | last5 = Arai | first5 = T. | last6 = Younes | first6 = M. | last7 = Kasumi | first7 = F. | last8 = Sakamoto | first8 = G. | title = Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast. | journal = Histopathology | volume = 47 | issue = 2 | pages = 195-201 | month = Aug | year = 2005 | doi = 10.1111/j.1365-2559.2005.02181.x | PMID = 16045781 }}</ref> | |||
*AR +ve. | |||
*[[GCDFP-15]] +ve. | |||
Usually:<ref name=Ref_BP217>{{Ref BP|217}}</ref> | |||
*ER -ve. | |||
*PR -ve. | |||
==See also== | |||
*[[Invasive breast cancer]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Invasive breast cancer]] | |||