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Glycogen-rich clear cell carcinoma of the breast (view source)
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'''Glycogen-rich_clear cell carcinoma of the breast''' is rare type of [[invasive breast cancer]]. | |||
It may be abbreviated '''GRCC'''. | |||
==General== | |||
*Very rare. | |||
*Possibly a variant of [[apocrine carcinoma of the breast|apocrine carcinoma]].<ref name=pmid7611537>{{Cite journal | last1 = Hayes | first1 = MM. | last2 = Seidman | first2 = JD. | last3 = Ashton | first3 = MA. | title = Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases. | journal = Am J Surg Pathol | volume = 19 | issue = 8 | pages = 904-11 | month = Aug | year = 1995 | doi = | PMID = 7611537 }} | |||
</ref> | |||
*Prognosis usu. poor. | |||
==Microscopic== | |||
Features: | |||
*Groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour.<ref name=pmid20551566>{{Cite journal | last1 = Thondavadi | first1 = SR. | last2 = Krishnamurthy | first2 = J. | last3 = Gubbanna | first3 = VM. | title = A case report of glycogen-rich clear cell carcinoma of breast. | journal = Indian J Pathol Microbiol | volume = 53 | issue = 2 | pages = 374-5 | month = | year = | doi = 10.4103/0377-4929.64289 | PMID = 20551566 | URL = http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=2;spage=374;epage=375;aulast=Thondavadi }}</ref> | |||
**Various architectural arrangements: cords, trabeculae, clusters, cribriform. | |||
**Minimal nuclear pleomorphism. | |||
Notes: | |||
*Histologic appearance may be similar to ''[[hyalinizing clear cell carcinoma]]''. | |||
DDx: | |||
*[[Signet-ring carcinoma]]. | |||
*Lipid-rich carcinoma. | |||
*[[Apocrine carcinoma of the breast|Apocrine carcinoma]]. | |||
*[[Secretory carcinoma of the breast|Secretory carcinoma]]. | |||
===Images=== | |||
www: | |||
*[http://www.ijpmonline.org/viewimage.asp?img=IndianJPatholMicrobiol_2010_53_2_374_64289_f1.jpg GRCC (ijpmonline.org)].<ref name=pmid20551566/> | |||
==Stains== | |||
Features:<ref name=pmid20551566/> | |||
*PAS +ve. | |||
*PASD -ve. | |||
Others:<ref name=pmid20551566/> | |||
*Oil red O -ve. | |||
**Lipid-rich carcinoma +ve. | |||
==IHC== | |||
Features:<ref name=pmid20551566/> | |||
*[[BRST2]] -ve. | |||
**Apocrine carcinoma +ve. | |||
==See also== | |||
*[[Invasive breast cancer]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Invasive breast cancer]] | |||