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Tubular carcinoma of the breast (view source)
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'''Tubular carcinoma of the breast''' is an uncommon for of [[invasive breast cancer]] that at first glance may look like benign breast tissue. | |||
*[[AKA]] ''tubular carcinoma''. | |||
==General== | |||
Epidemiology: | |||
*Typically excellent prognosis. | |||
*Hormone receptors commonly present (ER +ve, PR +ve). | |||
*Usually HER2 -ve. | |||
*Classically seen in post-menopausal women. | |||
Note: | |||
*May be seen in association with [[lobular carcinoma in situ]] and columnar cell lesions - known as '''Rosen triad'''.<ref name=pmid18434766>{{Cite journal | last1 = Brandt | first1 = SM. | last2 = Young | first2 = GQ. | last3 = Hoda | first3 = SA. | title = The "Rosen Triad": tubular carcinoma, lobular carcinoma in situ, and columnar cell lesions. | journal = Adv Anat Pathol | volume = 15 | issue = 3 | pages = 140-6 | month = May | year = 2008 | doi = 10.1097/PAP.0b013e31816ff313 | PMID = 18434766 }}</ref> | |||
**Memory device ''TLC'' = '''T'''ubular ca., '''L'''CIS, '''C'''olumnar cell lesions. | |||
==Microscopic== | |||
Features:<ref name=Ref_PBoD1146>{{Ref PBoD|1146}}</ref><ref>URL: [http://www.bweems.com/nsj3mp2.jpg http://www.bweems.com/nsj3mp2.jpg].</ref><ref>URL: [http://surgpathcriteria.stanford.edu/breast/tubularcabr/ http://surgpathcriteria.stanford.edu/breast/tubularcabr/].</ref> | |||
*Well-formed tubules. | |||
**Typically have angled ducts - "prows" - '''important feature''' (low power). | |||
**Myoepithelial cells absent - diagnostic - may be have to appreciated without IHC. | |||
**>70% of the tumour cells should be adjacent to lumen.<ref name=pmid10836300>{{Cite journal | last1 = Stalsberg | first1 = H. | last2 = Hartmann | first2 = WH. | title = The delimitation of tubular carcinoma of the breast. | journal = Hum Pathol | volume = 31 | issue = 5 | pages = 601-7 | month = May | year = 2000 | doi = | PMID = 10836300 }}</ref> | |||
*+/- Cribriform spaces. | |||
*Apocrine snouts typical. | |||
*+/-Calcification. | |||
Notes: | |||
*Prow = front of a ship. | |||
*Looks benign to the uninitiated -- '''important'''. | |||
DDx: | |||
*[[Sclerosing adenosis]]. | |||
*[[Microglandular adenosis]]. | |||
===Images=== | |||
www: | |||
*[http://radiology.uchc.edu/eAtlas/Breast/1714.htm Tubular carcinoma - (uchc.edu)]. | |||
==IHC== | |||
*ER +ve. | |||
*PR +ve. | |||
*HER2 -ve. | |||
**HER2 positivity should prompt consideration of another diagnosis! | |||
==See also== | |||
*[[Invasive breast cancer]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Invasive breast cancer]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||