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Invasive lobular carcinoma (view source)
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'''Invasive lobular carcinoma''', abbreviated '''ILC''', is the second most common form of [[Invasive breast cancer]]. | |||
It may be referred to as '''lobular carcinoma'''; however, this may lead to confusion with [[lobular carcinoma in situ]]. | |||
==General== | |||
*May be associated with a CDH1 mutation - seen in diffuse type [[stomach|gastric]] cancer.<ref>URL: [http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33006 http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33006]. Accessed on: 19 April 2011.</ref><ref name=omim192090>{{OMIM|192090}}</ref> | |||
==Microscopic== | |||
Features: | |||
*"Single file" - cell line-up in a row. | |||
**Cell should not be cohesive -- [[lymphoma]] should briefly come to mind. | |||
***primary lymphoma of the breast exists... but it is extremely rare. | |||
*NO gland formation. | |||
**If it forms glands... it is more likely NST. | |||
*May have [[signet ring cell|signet ring]] morphology. | |||
*NO [[desmoplastic reaction]], i.e. the stroma surrounding the tumour cells should look benign and undisturbed. | |||
Note: | |||
*Commonly have low grade nuclear features. | |||
===Images=== | |||
<gallery> | |||
Image:Lobular_carcinoma_-_low_mag.jpg | Lobular carcinoma - low mag. (WC/Nephron) | |||
Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - high mag. (WC/Nephron) | |||
Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - very high mag. (WC/Nephron) | |||
</gallery> | |||
More [[WC]] images: | |||
*[http://commons.wikimedia.org/wiki/File:Breast_invasive_lobular_carcinoma_%281%29.jpg Lobular carcinoma - 1 (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Breast_invasive_lobular_carcinoma_%282%29.jpg Lobular carcinoma - 2 (WC)]. | |||
===Subclassification=== | |||
*Classic lobular carcinoma. | |||
**Low nuclear grade - NO significant variation of nucleus size. | |||
*Pleomorphic lobular carcinoma. | |||
**Significant nuclear atypia. | |||
Note: | |||
*Some pathologist grade lobular carcinoma like other types and avoid the term "pleomorphic lobular carcinoma."<ref>MUA. Jan 22, 2009.</ref> | |||
==See also== | |||
*[[Invasive breast cancer]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Invasive breast cancer]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||