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Invasive ductal carcinoma of the breast (view source)
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'''Invasive ductal carcinoma of the breast''' is the most common form of [[invasive breast cancer]]. It arises from [[ductal carcinoma in situ]]. | |||
It is also known as '''NST''' (No Specific Type). Generically, it may be referred to as ''invasive mammary carcinoma''. | |||
==General== | |||
*Most common type of [[invasive breast cancer]]. | |||
==Microscopic== | |||
Features: | |||
*Atypical cells: | |||
**Usually >2x [[RBC]] diameter. | |||
**Nucleoli common. | |||
**Forming ducts ''or'' sheets. | |||
**+/-Mitoses. | |||
**+/-Necrosis. | |||
*Evidence of invasion: | |||
**Atypical nucleus adjacent to adipocyte - '''diagnostic'''. | |||
**"Infiltrative" pattern: | |||
***Small glands of variable size within desmoplastic stroma. | |||
***Glands lined by a single layer of cells. | |||
DDx: | |||
*[[DCIS]]. | |||
*[[Invasive lobular carcinoma]]. | |||
==IHC== | |||
Myoepithelial markers - '''diagnostic''' for invasion: | |||
*SMMS -ve. | |||
*p63 -ve. | |||
Prognostic markers - may be useful for metastates: | |||
*ER +ve (diffuse). | |||
*PR +ve (diffuse). | |||
*HER2 -ve. | |||
==See also== | |||
*[[Invasive breast cancer]]. | |||
*[[DCIS]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Invasive breast cancer]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||