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Mucinous breast carcinoma (view source)
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'''Mucinous breast carcinoma''' is an uncommon form of breast cancer that has a good prognosis compared to the common [[invasive ductal carcioma of the breast|ductal carcinoma]]. | |||
It is also known as '''mucinous carcinoma of the breast''', and '''colloid carcinoma of the breast'''. | |||
==General== | |||
*Rare. | |||
*Good prognosis.<ref name=pmid18809061>{{Cite journal | last1 = Barkley | first1 = CR. | last2 = Ligibel | first2 = JA. | last3 = Wong | first3 = JS. | last4 = Lipsitz | first4 = S. | last5 = Smith | first5 = BL. | last6 = Golshan | first6 = M. | title = Mucinous breast carcinoma: a large contemporary series. | journal = Am J Surg | volume = 196 | issue = 4 | pages = 549-51 | month = Oct | year = 2008 | doi = 10.1016/j.amjsurg.2008.06.013 | PMID = 18809061 }}</ref> | |||
*Usually older women. | |||
==Gross== | |||
*Pale, glistening, jelly-like appearance. | |||
*Well-circumscribed. | |||
Image: | |||
*[http://www.webpathology.com/image.asp?case=297&n=1 Mucinous carcinoma of the breast (webpathology.com)]. | |||
==Microscopic== | |||
Features: | |||
*Malignant mucin producing glands. | |||
**Mucinous component must comprise >90% of the tumour - '''required for diagnosis'''.<ref name=pmid22006768>{{Cite journal | last1 = Dogan | first1 = E. | last2 = Aksoy | first2 = S. | last3 = Dizdar | first3 = O. | last4 = Arslan | first4 = C. | last5 = Dede | first5 = DS. | last6 = Ozisik | first6 = Y. | last7 = Altundag | first7 = K. | title = Pure mucinous carcinoma of the breast: a single center experience. | journal = J BUON | volume = 16 | issue = 3 | pages = 565-7 | month = | year = | doi = | PMID = 22006768 }}</ref> | |||
**Cells should float in the mucin - '''key feature'''. | |||
**Glands typically have irregular edges. | |||
**+/-Vessels within the mucin pools. | |||
DDx: | |||
*[[DCIS]] with a mucinous component. | |||
**Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border. | |||
Note: | |||
*The amount of mucinous component to call ''[[mucinous carcinoma]]'' varies by anatomical site. | |||
*All mucinous lesions should be excised.<ref name=pmid12218567>{{Cite journal | last1 = Jacobs | first1 = TW. | last2 = Connolly | first2 = JL. | last3 = Schnitt | first3 = SJ. | title = Nonmalignant lesions in breast core needle biopsies: to excise or not to excise? | journal = Am J Surg Pathol | volume = 26 | issue = 9 | pages = 1095-110 | month = Sep | year = 2002 | doi = | PMID = 12218567 }}</ref> | |||
==IHC== | |||
*ER +ve. | |||
*PR +ve. | |||
*HER2 -ve. | |||
==See also== | |||
*[[Invasive breast cancer]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Invasive breast cancer]] | |||