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Difference between revisions of "Secretory carcinoma of the salivary gland"
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Secretory carcinoma of the salivary gland (view source)
Revision as of 01:36, 14 February 2014
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==General== | ==General== | ||
* | *Super rare - 21 cases in the world literature as of 2012.<ref name=pmid22127547/> | ||
*Has been described in pediatric patient.<ref name=pmid21873597>{{Cite journal | last1 = Rastatter | first1 = JC. | last2 = Jatana | first2 = KR. | last3 = Jennings | first3 = LJ. | last4 = Melin-Aldana | first4 = H. | title = Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient. | journal = Otolaryngol Head Neck Surg | volume = 146 | issue = 3 | pages = 514-5 | month = Mar | year = 2012 | doi = 10.1177/0194599811419044 | PMID = 21873597 }}</ref> | |||
*Microscopic appearance similar to [[secretory carcinoma]].<ref name=pmid20410810>{{Cite journal | last1 = Skálová | first1 = A. | last2 = Vanecek | first2 = T. | last3 = Sima | first3 = R. | last4 = Laco | first4 = J. | last5 = Weinreb | first5 = I. | last6 = Perez-Ordonez | first6 = B. | last7 = Starek | first7 = I. | last8 = Geierova | first8 = M. | last9 = Simpson | first9 = RH. | title = Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. | journal = Am J Surg Pathol | volume = 34 | issue = 5 | pages = 599-608 | month = May | year = 2010 | doi = 10.1097/PAS.0b013e3181d9efcc | PMID = 20410810 }}</ref> | |||
==Gross== | |||
*Usually parotid gland.<ref name=pmid20410810/> | |||
*Well-circumscribed.{{fact}} | |||
==Microscopic== | ==Microscopic== | ||
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*Small nuclei. | *Small nuclei. | ||
*+/-Lymphocytic infiltrate. | *+/-Lymphocytic infiltrate. | ||
*Solid and microcystic growth pattern. | |||
DDx: | DDx: | ||
*[[Acinic cell carcinoma]] - very closely mimics. | *[[Acinic cell carcinoma]] - very closely mimics. | ||
**Abundant basophilic granular cytoplasm.<ref name=pmid22127547/> | |||
*[[Mucoepidermoid carcinoma]]. | *[[Mucoepidermoid carcinoma]]. | ||
===Images=== | ===Images=== | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig2/ MASC (nih.gov)].<ref name=pmid22127547/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig2/ MASC (nih.gov)].<ref name=pmid22127547/> | ||
==Stains== | |||
Features:<ref name=pmid20410810/> | |||
*[[PAS stain]] +ve. | |||
*[[Mucicarmine stain]] +ve. | |||
==IHC== | ==IHC== | ||
Features:<ref name=pmid20410810/> | |||
*S-100 +ve.<ref name=pmid22127547/> | *S-100 +ve.<ref name=pmid22127547/> | ||
*Mammomglobin +ve. | |||
*Vimentin +ve. | |||
==Molecular== | ==Molecular== | ||