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Difference between revisions of "Neuropathology tumours"
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Neuropathology tumours (view source)
Revision as of 05:40, 24 November 2010
, 05:40, 24 November 2010→Glioblastoma IHC: more
(→Pilocytic astrocytoma: more, +pilomyxoid astrocytoma) |
(→Glioblastoma IHC: more) |
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===Glioblastoma IHC=== | ===Glioblastoma IHC=== | ||
*GFAP - should stain cytoplasm of tumour cells and the perikaryon (nuclear membrane). | *GFAP - should stain cytoplasm of tumour cells and the perikaryon (nuclear membrane). | ||
*Ki-67. | *Ki-67 - usu. high >20% of cells. | ||
*p53. | *p53 - often +ve. | ||
*IDH1. | *IDH1 (isocitrate dehydrogenase 1). | ||
**+ve in tumours that arose from low-grade gliomas.<ref name=pmid19228619>PMID 19228619.</ref> | **+ve in tumours that arose from low-grade gliomas.<ref name=pmid19228619>PMID 19228619.</ref> | ||
***Image: [http://en.wikipedia.org/wiki/File:IDH1_GBM_20x.jpg IDH1 +ve in glioblastoma (WP)]. | ***Image: [http://en.wikipedia.org/wiki/File:IDH1_GBM_20x.jpg IDH1 +ve in glioblastoma (WP)]. | ||